A conserved VPS34-PIKfyve-TRPML1-myosin II axis regulates the speed of amoeboid cell migration.

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Title: A conserved VPS34-PIKfyve-TRPML1-myosin II axis regulates the speed of amoeboid cell migration.
Authors: Dehio P; Department of Biomedicine, Immunobiology, University and University Hospital of Basel, Basel, Switzerland.; Institute of Science and Technology Austria, Klosterneuburg, Austria., Michard C; Department of Biochemistry, Faculty of Science, University of Geneva, Geneva, Switzerland., Yam-Puc JC; MRC Toxicology Unit, University of Cambridge, Cambridge, UK., Martí I Líndez AA; Department of Medicine, CITIID, University of Cambridge, Cambridge, UK., Jandke A; Department of Biomedicine, Immunobiology, University and University Hospital of Basel, Basel, Switzerland., Unterstab G; Department of Biomedicine, Immunobiology, University and University Hospital of Basel, Basel, Switzerland., Fabre L; Department of Biomedicine, Immunobiology, University and University Hospital of Basel, Basel, Switzerland., Sauteur L; Microscopy Core Facility, Department of Biomedicine, University of Basel, Basel, Switzerland., Artinger M; Institute of Cell Biology and Immunology Thurgau, University of Konstanz, Kreuzlingen, Switzerland., Legler DF; Institute of Cell Biology and Immunology Thurgau, University of Konstanz, Kreuzlingen, Switzerland.; Theodor Kocher Institute, University of Bern, Bern, Switzerland.; Faculty of Biology, University of Konstanz, Konstanz, Germany., Sixt M; Institute of Science and Technology Austria, Klosterneuburg, Austria., Schaefer T; Department of Biomedicine, Cancer- and Immunobiology, University of Basel, Basel, Switzerland., Wymann MP; Department of Biomedicine, Cancer- and Immunobiology, University of Basel, Basel, Switzerland., Okkenhaug K; Department of Pathology, University of Cambridge, Cambridge, UK., Soldati T; Department of Biochemistry, Faculty of Science, University of Geneva, Geneva, Switzerland., Mehling M; Department of Biomedicine, Translational Neuroimmunology, University of Basel and University Hospital Basel, Basel, Switzerland., Hess C; Department of Biomedicine, Immunobiology, University and University Hospital of Basel, Basel, Switzerland. ch818@cam.ac.uk.; Department of Medicine, CITIID, University of Cambridge, Cambridge, UK. ch818@cam.ac.uk.
Source: EMBO reports [EMBO Rep] 2026 Jul 07. Date of Electronic Publication: 2026 Jul 07.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1469-3178
DOI:10.1038/s44319-026-00861-x