Astrocyte-derived HMGB1 compromises the integrity of the blood-brain barrier through the CaM/CaMKII/AQP4 pathway and the protective function of trifluoperazine.
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| Title: | Astrocyte-derived HMGB1 compromises the integrity of the blood-brain barrier through the CaM/CaMKII/AQP4 pathway and the protective function of trifluoperazine. |
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| Authors: | Zou SS; Key Laboratory of Exploitation and Study of Distinctive Plants of Sichuan Provincial Education Department, Sichuan University of Arts and Science, Dazhou, China.; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Centre for Sustainable Pig Production, Hubei Jiangxia Laboratory, Wuhan, Hubei, China.; Key Laboratory of Development of Veterinary Diagnostic Products, Ministry of Agriculture of the People's Republic of China, Wuhan, Hubei, China.; International Research Centre for Animal Disease, Ministry of Science and Technology of the People's Republic of China, Wuhan, Hubei, China.; Dazhou Traditional Chinese Medicine (TCM) Research and Development Centre (R&D), Dazhou, China.; Dazhou TCM Industry Incubation Center, Dazhou, China., Chen LL; Key Laboratory of Exploitation and Study of Distinctive Plants of Sichuan Provincial Education Department, Sichuan University of Arts and Science, Dazhou, China.; Dazhou Traditional Chinese Medicine (TCM) Research and Development Centre (R&D), Dazhou, China.; Dazhou TCM Industry Incubation Center, Dazhou, China., Cui M; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Centre for Sustainable Pig Production, Hubei Jiangxia Laboratory, Wuhan, Hubei, China.; Key Laboratory of Development of Veterinary Diagnostic Products, Ministry of Agriculture of the People's Republic of China, Wuhan, Hubei, China.; International Research Centre for Animal Disease, Ministry of Science and Technology of the People's Republic of China, Wuhan, Hubei, China. |
| Source: | Frontiers in immunology [Front Immunol] 2026 Jun 23; Vol. 17, pp. 1852083. Date of Electronic Publication: 2026 Jun 23 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1664-3224 |
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| DOI: | 10.3389/fimmu.2026.1852083 |
