Is Dose Reduction After Initial Treatment With Denosumab Associated With Subsequent Skeletal-related Events, Osteonecrosis of the Jaw, or Osteoporotic Fractures in Patients With Metastatic Carcinoma? A Nationwide Retrospective Comparative Study.

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Title: Is Dose Reduction After Initial Treatment With Denosumab Associated With Subsequent Skeletal-related Events, Osteonecrosis of the Jaw, or Osteoporotic Fractures in Patients With Metastatic Carcinoma? A Nationwide Retrospective Comparative Study.
Authors: Heng XQ; Department of Medical Education, National Taiwan University Hospital, Taipei, Taiwan., Lin WH; Department of Orthopaedic Surgery, National Taiwan University Hospital, Taipei, Taiwan., Yeh CC; Department of Orthopaedic Surgery, National Taiwan University Hospital, Hsin-Chu Branch, Hsin-Chu, Taiwan., Liu LY; Department of Medical Education, National Taiwan University Hospital, Taipei, Taiwan., Chung CH; Department of Medical Education, National Taiwan University Hospital, Taipei, Taiwan., Yen HK; Department of Orthopaedic Surgery, National Taiwan University Hospital, Taipei, Taiwan., Chang FL; Department of Orthopaedic Surgery, National Taiwan University Hospital, Taipei, Taiwan.; Department of Nursing, National Taiwan University Hospital, Taipei, Taiwan., Chen HM; National Taiwan University Health Data Research Center, Taipei, Taiwan., Hu MH; Department of Orthopaedic Surgery, National Taiwan University Hospital, Taipei, Taiwan., Fu SH; Department of Orthopaedic Surgery, National Taiwan University Hospital, Douliu Branch, Yunlin, Taiwan., Wang CY; National Center for Geriatrics and Welfare Research, National Health Research Institutes, Huwei Township, Yunlin County, Taiwan.; Department of Pharmacy, National Taiwan University Hospital Yun-Lin Branch, Douliu City, Yunlin County, Taiwan., Groot OQ; Department of Orthopaedics, University Medical Center Utrecht, Utrecht, the Netherlands.
Source: Clinical orthopaedics and related research [Clin Orthop Relat Res] 2026 Jul 07. Date of Electronic Publication: 2026 Jul 07.
Publication Type: Journal Article
Journal Info: Publisher: Wolters Kluwer Country of Publication: United States NLM ID: 0075674 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-1132 (Electronic) Linking ISSN: 0009921X NLM ISO Abbreviation: Clin Orthop Relat Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1528-1132
DOI:10.1097/CORR.0000000000004052