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Is Dose Reduction After Initial Treatment With Denosumab Associated With Subsequent Skeletal-related Events, Osteonecrosis of the Jaw, or Osteoporotic Fractures in Patients With Metastatic Carcinoma? A Nationwide Retrospective Comparative Study.

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Title: Is Dose Reduction After Initial Treatment With Denosumab Associated With Subsequent Skeletal-related Events, Osteonecrosis of the Jaw, or Osteoporotic Fractures in Patients With Metastatic Carcinoma? A Nationwide Retrospective Comparative Study.
Authors: Heng XQ; Department of Medical Education, National Taiwan University Hospital, Taipei, Taiwan., Lin WH; Department of Orthopaedic Surgery, National Taiwan University Hospital, Taipei, Taiwan., Yeh CC; Department of Orthopaedic Surgery, National Taiwan University Hospital, Hsin-Chu Branch, Hsin-Chu, Taiwan., Liu LY; Department of Medical Education, National Taiwan University Hospital, Taipei, Taiwan., Chung CH; Department of Medical Education, National Taiwan University Hospital, Taipei, Taiwan., Yen HK; Department of Orthopaedic Surgery, National Taiwan University Hospital, Taipei, Taiwan., Chang FL; Department of Orthopaedic Surgery, National Taiwan University Hospital, Taipei, Taiwan.; Department of Nursing, National Taiwan University Hospital, Taipei, Taiwan., Chen HM; National Taiwan University Health Data Research Center, Taipei, Taiwan., Hu MH; Department of Orthopaedic Surgery, National Taiwan University Hospital, Taipei, Taiwan., Fu SH; Department of Orthopaedic Surgery, National Taiwan University Hospital, Douliu Branch, Yunlin, Taiwan., Wang CY; National Center for Geriatrics and Welfare Research, National Health Research Institutes, Huwei Township, Yunlin County, Taiwan.; Department of Pharmacy, National Taiwan University Hospital Yun-Lin Branch, Douliu City, Yunlin County, Taiwan., Groot OQ; Department of Orthopaedics, University Medical Center Utrecht, Utrecht, the Netherlands.
Source: Clinical orthopaedics and related research [Clin Orthop Relat Res] 2026 Jul 07. Date of Electronic Publication: 2026 Jul 07.
Publication Type: Journal Article
Journal Info: Publisher: Wolters Kluwer Country of Publication: United States NLM ID: 0075674 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-1132 (Electronic) Linking ISSN: 0009921X NLM ISO Abbreviation: Clin Orthop Relat Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Is Dose Reduction After Initial Treatment With Denosumab Associated With Subsequent Skeletal-related Events, Osteonecrosis of the Jaw, or Osteoporotic Fractures in Patients With Metastatic Carcinoma? A Nationwide Retrospective Comparative Study.
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  Data: <searchLink fieldCode="AU" term="%22Heng+XQ%22">Heng XQ</searchLink>; Department of Medical Education, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+WH%22">Lin WH</searchLink>; Department of Orthopaedic Surgery, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yeh+CC%22">Yeh CC</searchLink>; Department of Orthopaedic Surgery, National Taiwan University Hospital, Hsin-Chu Branch, Hsin-Chu, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+LY%22">Liu LY</searchLink>; Department of Medical Education, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chung+CH%22">Chung CH</searchLink>; Department of Medical Education, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yen+HK%22">Yen HK</searchLink>; Department of Orthopaedic Surgery, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chang+FL%22">Chang FL</searchLink>; Department of Orthopaedic Surgery, National Taiwan University Hospital, Taipei, Taiwan.; Department of Nursing, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+HM%22">Chen HM</searchLink>; National Taiwan University Health Data Research Center, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hu+MH%22">Hu MH</searchLink>; Department of Orthopaedic Surgery, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Fu+SH%22">Fu SH</searchLink>; Department of Orthopaedic Surgery, National Taiwan University Hospital, Douliu Branch, Yunlin, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+CY%22">Wang CY</searchLink>; National Center for Geriatrics and Welfare Research, National Health Research Institutes, Huwei Township, Yunlin County, Taiwan.; Department of Pharmacy, National Taiwan University Hospital Yun-Lin Branch, Douliu City, Yunlin County, Taiwan.<br /><searchLink fieldCode="AU" term="%22Groot+OQ%22">Groot OQ</searchLink>; Department of Orthopaedics, University Medical Center Utrecht, Utrecht, the Netherlands.
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  Data: <searchLink fieldCode="JN" term="%220075674%22">Clinical orthopaedics and related research</searchLink> [Clin Orthop Relat Res] 2026 Jul 07. <i>Date of Electronic Publication: </i>2026 Jul 07.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Wolters+Kluwer%22">Wolters Kluwer </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0075674 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1528-1132 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220009921X%22">0009921X </searchLink><i>NLM ISO Abbreviation: </i>Clin Orthop Relat Res <i>Subsets: </i>MEDLINE
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        Value: 10.1097/CORR.0000000000004052
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        Text: English
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      – TitleFull: Is Dose Reduction After Initial Treatment With Denosumab Associated With Subsequent Skeletal-related Events, Osteonecrosis of the Jaw, or Osteoporotic Fractures in Patients With Metastatic Carcinoma? A Nationwide Retrospective Comparative Study.
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              Text: 2026 Jul 07
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              Y: 2026
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