Complex intervention programme to improve patient safety and facilitate deprescribing in frail older patients living at home (COFRAIL): A process evaluation of a cluster randomised controlled trial.

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Title: Complex intervention programme to improve patient safety and facilitate deprescribing in frail older patients living at home (COFRAIL): A process evaluation of a cluster randomised controlled trial.
Authors: Abraham J; Institute of Health, Midwifery and Nursing Science, Medical Faculty of Martin Luther University Halle-Wittenberg, Halle (Saale), Germany., Fleischer S; Institute of Health, Midwifery and Nursing Science, Medical Faculty of Martin Luther University Halle-Wittenberg, Halle (Saale), Germany., Mortsiefer A; Faculty of Health, Department of Medicine, Institute of General Practice and Primary Care, Witten/Herdecke University, Witten, Germany., Drewelow E; Clinic for Forensic Psychiatry, University Medical Centre Rostock, Rostock, Germany., Ritzke M; Institute of General Practice, University Medical Centre Rostock, Rostock, Germany., Wiese B; WG Medical Statistics and IT-Infrastructure, Institute of General Practice, Hannover Medical School, Hannover, Germany., Dintsios CM; Faculty of Medicine, Institute for Health Services Research and Health Economics, Centre for Health and Society, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany., Bencheva V; Faculty of Health, Center for Clinical Trials, Witten/Herdecke University, Witten, Germany.; Chair of Clinical Pharmacology, Department of Medicine, Faculty of Health, Witten/Herdecke University, Witten, Germany., Thürmann P; Chair of Clinical Pharmacology, Department of Medicine, Faculty of Health, Witten/Herdecke University, Witten, Germany.; Philipp Klee-Institute of Clinical Pharmacology, Helios University Hospital Wuppertal, Wuppertal, Germany., Wilm S; Institute of General Practice, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany., Meyer G; Institute of Health, Midwifery and Nursing Science, Medical Faculty of Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
Corporate Authors: COFRAIL study group
Source: PloS one [PLoS One] 2026 Jul 08; Vol. 21 (7), pp. e0350664. Date of Electronic Publication: 2026 Jul 08 (Print Publication: 2026).
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1932-6203
DOI:10.1371/journal.pone.0350664