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Transcriptional perturbation of LINE-1 elements reveals their cis-regulatory potential.

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Title: Transcriptional perturbation of LINE-1 elements reveals their cis-regulatory potential.
Authors: Pérez-Rico YA; Directors' Research, European Molecular Biology Laboratory, Heidelberg, Germany., Le Breton A; GIMM - Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal.; Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal., Bousard A; Genetics and Developmental Biology Unit, Institut Curie, PSL Research University, CNRS UMR3215, INSERM U934, Paris, France., Henao Misikova L; GIMM - Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal., Mulugeta E; Genetics and Developmental Biology Unit, Institut Curie, PSL Research University, CNRS UMR3215, INSERM U934, Paris, France.; Department of Internal Medicine, Endocrine Tumor Laboratory, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands., de Almeida SF; GIMM - Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal.; Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal., Muotri AR; Departments of Pediatrics and Cellular & Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, USA., Heard E; Directors' Research, European Molecular Biology Laboratory, Heidelberg, Germany.; Genetics and Developmental Biology Unit, Institut Curie, PSL Research University, CNRS UMR3215, INSERM U934, Paris, France.; Collège de France, Paris, France.; The Francis Crick Institute, London, UK., Gendrel AV; GIMM - Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal. anne-valerie.gendrel@gimm.pt.; Genetics and Developmental Biology Unit, Institut Curie, PSL Research University, CNRS UMR3215, INSERM U934, Paris, France. anne-valerie.gendrel@gimm.pt.
Source: EMBO reports [EMBO Rep] 2026 Jul 08. Date of Electronic Publication: 2026 Jul 08.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Pérez-Rico+YA%22">Pérez-Rico YA</searchLink>; Directors' Research, European Molecular Biology Laboratory, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Le+Breton+A%22">Le Breton A</searchLink>; GIMM - Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal.; Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Bousard+A%22">Bousard A</searchLink>; Genetics and Developmental Biology Unit, Institut Curie, PSL Research University, CNRS UMR3215, INSERM U934, Paris, France.<br /><searchLink fieldCode="AU" term="%22Henao+Misikova+L%22">Henao Misikova L</searchLink>; GIMM - Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Mulugeta+E%22">Mulugeta E</searchLink>; Genetics and Developmental Biology Unit, Institut Curie, PSL Research University, CNRS UMR3215, INSERM U934, Paris, France.; Department of Internal Medicine, Endocrine Tumor Laboratory, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Almeida+SF%22">de Almeida SF</searchLink>; GIMM - Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal.; Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Muotri+AR%22">Muotri AR</searchLink>; Departments of Pediatrics and Cellular & Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Heard+E%22">Heard E</searchLink>; Directors' Research, European Molecular Biology Laboratory, Heidelberg, Germany.; Genetics and Developmental Biology Unit, Institut Curie, PSL Research University, CNRS UMR3215, INSERM U934, Paris, France.; Collège de France, Paris, France.; The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Gendrel+AV%22">Gendrel AV</searchLink>; GIMM - Gulbenkian Institute for Molecular Medicine, Lisbon, Portugal. anne-valerie.gendrel@gimm.pt.; Genetics and Developmental Biology Unit, Institut Curie, PSL Research University, CNRS UMR3215, INSERM U934, Paris, France. anne-valerie.gendrel@gimm.pt.
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              Text: 2026 Jul 08
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