C1q and immunoglobulins mediate activity-dependent synapse loss in the adult brain.
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| Title: | C1q and immunoglobulins mediate activity-dependent synapse loss in the adult brain. |
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| Authors: | Crowley G; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK., Kim M; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK., O'Neill N; Research Department of Epilepsy, Queen Square Institute of Neurology, University College London, London, UK., Turkes E; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK., Ghasemi F; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Giudice L; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., De Schepper S; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK., Tan BJY; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK.; Cambridge Institute of Therapeutic Immunology and Infectious Diseases, University of Cambridge, Cambridge, UK., Maffei B; Research Department of Epilepsy, Queen Square Institute of Neurology, University College London, London, UK., S S Ferreira L; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK., Rebejac J; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK., Rueda-Carrasco J; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK., Toneva M; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK., Fajardo JC; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK., Ge JZ; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK., Yang ZG; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK., Korhonen P; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Muckett P; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK., Bennett D; The Francis Crick Institute, London, UK., Paoletti C; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK., Sow TTM; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK., Posner DA; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK.; Cambridge Institute of Therapeutic Immunology and Infectious Diseases, University of Cambridge, Cambridge, UK., Sierksma A; VIB-KU Leuven Center for Neuroscience, Leuven, Belgium.; Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute, Katholieke Universiteit Leuven, Leuven, Belgium., Sokolova D; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK., Konstantellos V; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK., Ali L; Brain and Systems Immunology Laboratory, Brussels Center for Immunology, Vrije Universiteit Brussel, Brussels, Belgium.; Laboratory of Myeloid Cell Immunology, VIB Center for Inflammation Research, Brussels, Belgium., Movahedi K; Brain and Systems Immunology Laboratory, Brussels Center for Immunology, Vrije Universiteit Brussel, Brussels, Belgium., MacAskill AF; Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK., Tybulewicz VLJ; The Francis Crick Institute, London, UK., Malm T; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Lignani G; Research Department of Epilepsy, Queen Square Institute of Neurology, University College London, London, UK., Clatworthy MR; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK.; Cambridge Institute of Therapeutic Immunology and Infectious Diseases, University of Cambridge, Cambridge, UK.; Cellular Genetics, Wellcome Sanger Institute, Hinxton, UK., Hong S; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK. |
| Source: | Science (New York, N.Y.) [Science] 2026 Jul 09; Vol. 393 (6807), pp. eadv1219. Date of Electronic Publication: 2026 Jul 09. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1095-9203 |
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| DOI: | 10.1126/science.adv1219 |
