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C1q and immunoglobulins mediate activity-dependent synapse loss in the adult brain.

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Title: C1q and immunoglobulins mediate activity-dependent synapse loss in the adult brain.
Authors: Crowley G; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK., Kim M; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK., O'Neill N; Research Department of Epilepsy, Queen Square Institute of Neurology, University College London, London, UK., Turkes E; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK., Ghasemi F; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Giudice L; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., De Schepper S; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK., Tan BJY; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK.; Cambridge Institute of Therapeutic Immunology and Infectious Diseases, University of Cambridge, Cambridge, UK., Maffei B; Research Department of Epilepsy, Queen Square Institute of Neurology, University College London, London, UK., S S Ferreira L; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK., Rebejac J; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK., Rueda-Carrasco J; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK., Toneva M; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK., Fajardo JC; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK., Ge JZ; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK., Yang ZG; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK., Korhonen P; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Muckett P; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK., Bennett D; The Francis Crick Institute, London, UK., Paoletti C; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK., Sow TTM; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK., Posner DA; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK.; Cambridge Institute of Therapeutic Immunology and Infectious Diseases, University of Cambridge, Cambridge, UK., Sierksma A; VIB-KU Leuven Center for Neuroscience, Leuven, Belgium.; Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute, Katholieke Universiteit Leuven, Leuven, Belgium., Sokolova D; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK., Konstantellos V; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK., Ali L; Brain and Systems Immunology Laboratory, Brussels Center for Immunology, Vrije Universiteit Brussel, Brussels, Belgium.; Laboratory of Myeloid Cell Immunology, VIB Center for Inflammation Research, Brussels, Belgium., Movahedi K; Brain and Systems Immunology Laboratory, Brussels Center for Immunology, Vrije Universiteit Brussel, Brussels, Belgium., MacAskill AF; Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK., Tybulewicz VLJ; The Francis Crick Institute, London, UK., Malm T; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Lignani G; Research Department of Epilepsy, Queen Square Institute of Neurology, University College London, London, UK., Clatworthy MR; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK.; Cambridge Institute of Therapeutic Immunology and Infectious Diseases, University of Cambridge, Cambridge, UK.; Cellular Genetics, Wellcome Sanger Institute, Hinxton, UK., Hong S; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK.
Source: Science (New York, N.Y.) [Science] 2026 Jul 09; Vol. 393 (6807), pp. eadv1219. Date of Electronic Publication: 2026 Jul 09.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
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  Data: C1q and immunoglobulins mediate activity-dependent synapse loss in the adult brain.
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  Data: <searchLink fieldCode="AU" term="%22Crowley+G%22">Crowley G</searchLink>; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Kim+M%22">Kim M</searchLink>; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22O'Neill+N%22">O'Neill N</searchLink>; Research Department of Epilepsy, Queen Square Institute of Neurology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Turkes+E%22">Turkes E</searchLink>; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Ghasemi+F%22">Ghasemi F</searchLink>; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Giudice+L%22">Giudice L</searchLink>; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22De+Schepper+S%22">De Schepper S</searchLink>; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Tan+BJY%22">Tan BJY</searchLink>; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK.; Cambridge Institute of Therapeutic Immunology and Infectious Diseases, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Maffei+B%22">Maffei B</searchLink>; Research Department of Epilepsy, Queen Square Institute of Neurology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22S+S+Ferreira+L%22">S S Ferreira L</searchLink>; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Rebejac+J%22">Rebejac J</searchLink>; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Rueda-Carrasco+J%22">Rueda-Carrasco J</searchLink>; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Toneva+M%22">Toneva M</searchLink>; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Fajardo+JC%22">Fajardo JC</searchLink>; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Ge+JZ%22">Ge JZ</searchLink>; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Yang+ZG%22">Yang ZG</searchLink>; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Korhonen+P%22">Korhonen P</searchLink>; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Muckett+P%22">Muckett P</searchLink>; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Bennett+D%22">Bennett D</searchLink>; The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Paoletti+C%22">Paoletti C</searchLink>; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Sow+TTM%22">Sow TTM</searchLink>; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Posner+DA%22">Posner DA</searchLink>; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK.; Cambridge Institute of Therapeutic Immunology and Infectious Diseases, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Sierksma+A%22">Sierksma A</searchLink>; VIB-KU Leuven Center for Neuroscience, Leuven, Belgium.; Laboratory for the Research of Neurodegenerative Diseases, Department of Neurosciences, Leuven Brain Institute, Katholieke Universiteit Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Sokolova+D%22">Sokolova D</searchLink>; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Konstantellos+V%22">Konstantellos V</searchLink>; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Ali+L%22">Ali L</searchLink>; Brain and Systems Immunology Laboratory, Brussels Center for Immunology, Vrije Universiteit Brussel, Brussels, Belgium.; Laboratory of Myeloid Cell Immunology, VIB Center for Inflammation Research, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Movahedi+K%22">Movahedi K</searchLink>; Brain and Systems Immunology Laboratory, Brussels Center for Immunology, Vrije Universiteit Brussel, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22MacAskill+AF%22">MacAskill AF</searchLink>; Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Tybulewicz+VLJ%22">Tybulewicz VLJ</searchLink>; The Francis Crick Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Malm+T%22">Malm T</searchLink>; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Lignani+G%22">Lignani G</searchLink>; Research Department of Epilepsy, Queen Square Institute of Neurology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Clatworthy+MR%22">Clatworthy MR</searchLink>; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK.; Cambridge Institute of Therapeutic Immunology and Infectious Diseases, University of Cambridge, Cambridge, UK.; Cellular Genetics, Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Hong+S%22">Hong S</searchLink>; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK.
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