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Immunogenicity and safety of Papilloguard® 4, the first quadrivalent HPV vaccine combined with adjuvant system 04, versus Gardasil® in healthy 15-25-year-old individuals: a phase III, randomized, double-blind, non-inferiority trial.

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Title: Immunogenicity and safety of Papilloguard® 4, the first quadrivalent HPV vaccine combined with adjuvant system 04, versus Gardasil® in healthy 15-25-year-old individuals: a phase III, randomized, double-blind, non-inferiority trial.
Authors: Mardani M; Infectious Diseases Department, Shahid Beheshti Medical University, Tehran, Iran., Darazam IA; Infectious Diseases Department, Shahid Beheshti Medical University, Tehran, Iran., Moini A; Department of Gynecology and Obstetrics, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran., Ebrahimi A; Orchid Pharmed Company, Tehran, Iran. Electronic address: ebrahimi.a@orchidpharmed.com., Mirhassani R; Nivad Pharmed Salamat, Tehran, Iran. Electronic address: R.mirhassani@nivadpharmed.com., Barati S; Medical Department, Orchid Pharmed Company, Tehran, Iran. Electronic address: barati.s@orchidpharmed.com., Shahpari R; Medical Department, Orchid Pharmed Company, Tehran, Iran. Electronic address: shahpari.r@orchidpharmed.com., Modiri G; Orchid Pharmed Company, Tehran, Iran. Electronic address: modiri.g@orchidpharmed.com., Fallah N; Medical Department, Orchid Pharmed Company, Tehran, Iran. Electronic address: fallah.n@orchidpharmed.com., Albooyeh S; Orchid Pharmed Company, Tehran, Iran. Electronic address: albooyeh.s@orchidpharmed.com., Neyshaburinezhad N; Nivad Pharmed Salamat, Tehran, Iran., Karimi-Zarchi M; Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran., Kashanian M; Iran University of Medical Sciences, Tehran, Iran., Sabzvari A; CinnaGen Medical Biotechnology Research Center, Alborz University of Medical Sciences, Karaj, Iran. Electronic address: sabzvari.a@orchidpharmed.com., Kafi H; Medical Department, Orchid Pharmed Company, Tehran, Iran. Electronic address: kafi.h@orchidpharmed.com.
Source: Vaccine [Vaccine] 2026 Jul 08; Vol. 88, pp. 128886. Date of Electronic Publication: 2026 Jul 08.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8406899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2518 (Electronic) Linking ISSN: 0264410X NLM ISO Abbreviation: Vaccine Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1873-2518
DOI:10.1016/j.vaccine.2026.128886