Cross-definition GWAS of IBS in 2.8 million individuals reveals cardiometabolic and triglyceride-linked mechanisms.

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Title: Cross-definition GWAS of IBS in 2.8 million individuals reveals cardiometabolic and triglyceride-linked mechanisms.
Authors: Di Lorenzo B; Department of Medicine and Surgery, LUM University, Casamassima, Italy., Camargo Tavares L; National Centre for Epidemiology and Population Health, Australian National University, Canberra, Australian Capital Territory, Australia.; Hypertension Research Laboratory, Department of Pharmacology, Biomedical Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.; Gastroenterology Unit, Massachusetts General Hospital, Boston, MA, USA.; Clinical Translational Epidemiology Unit, Mongan Institute, Massachusetts General Hospital, Boston, MA, USA., Díaz-Muñoz C; Gastrointestinal Genetics Lab, CIC bioGUNE - BRTA, Derio, Spain., Heredia-Fernández F; Gastrointestinal Genetics Lab, CIC bioGUNE - BRTA, Derio, Spain., Bozzarelli I; Department of Medicine and Surgery, LUM University, Casamassima, Italy., Esteban Blanco C; Gastrointestinal Genetics Lab, CIC bioGUNE - BRTA, Derio, Spain., Wang Z; Department of Epidemiology, University of Alabama at Birmingham Health System, Birmingham, AL, USA.; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Smit RAJ; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Loos RJF; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hirbo J; Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetic Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Cox NJ; Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetic Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Straub P; Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetic Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Favé MJ; Centre for Structural and Functional Genomics, Department of Biology, Concordia University, Montréal, Quebec, Canada.; Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Awadalla P; Molecular Genetics, University of Oxford, Oxford, UK.; Big Data Institute, Nuffield Department of Health, University of Oxford, Oxford, UK., Pozdeyev N; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA.; Division of Endocrinology, Diabetes and Metabolism, University of Colorado Anschutz, Aurora, CO, USA.; Colorado Center for Personalized Medicine, University of Colorado Anschutz, Aurora, CO, USA.; University of Colorado Cancer Center, University of Colorado Anschutz, Aurora, CO, USA., Gignoux CR; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA.; Colorado Center for Personalized Medicine, University of Colorado Anschutz, Aurora, CO, USA.; University of Colorado Cancer Center, University of Colorado Anschutz, Aurora, CO, USA.; Human Medical Genetics and Genomics Program, University of Colorado Anschutz, Aurora, CO, USA., Gudbjartsson DF; Amgen deCODE Genetics, Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland., Thorleifsson G; Amgen deCODE Genetics, Reykjavik, Iceland., Jonsdottir I; Amgen deCODE Genetics, Reykjavik, Iceland.; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland., Stefansson K; Amgen deCODE Genetics, Reykjavik, Iceland.; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland., Abner E; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Palta P; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Williams AT; Division of Public Health and Epidemiology, School of Medical Sciences, University of Leicester, Leicester, UK., Coley K; Division of Public Health and Epidemiology, School of Medical Sciences, University of Leicester, Leicester, UK.; University Hospitals of Leicester NHS Trust, Leicester, UK., Sze G; Division of Public Health and Epidemiology, School of Medical Sciences, University of Leicester, Leicester, UK.; University Hospitals of Leicester NHS Trust, Leicester, UK., John C; Division of Public Health and Epidemiology, School of Medical Sciences, University of Leicester, Leicester, UK.; University Hospitals of Leicester NHS Trust, Leicester, UK., Richmond A; Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., McCartney D; Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Hayward C; Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Mulford AJ; Genomic Health Initiative, Endeavor Health, Evanston, IL, USA., Sanders AR; Genomic Health Initiative, Endeavor Health, Evanston, IL, USA.; Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, IL, USA., Peculis R; Latvian Biomedical Research and Study Centre, Riga, Latvia., Rovite V; Latvian Biomedical Research and Study Centre, Riga, Latvia., Dombrovska MS; Latvian Biomedical Research and Study Centre, Riga, Latvia., Capasso M; Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy.; CEINGE Biotecnologie Avanzate Franco Salvatore s.c.a r.l, Naples, Italy., Lo Faro V; Institute for Genetics and Biomedical Research, National Research Council, Cagliari, Italy.; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Sinha T; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Lopera Maya EA; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Zhernakova A; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Wang Y; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Martin A; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Vanderwerff B; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, University of Michigan, Ann Arbor, MI, USA., Zöllner S; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, University of Michigan, Ann Arbor, MI, USA.; Department of Psychiatry, University of Michigan School of Medicine, University of Michigan, Ann Arbor, MI, USA., Ferolito BR; Million Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, Boston, MA, USA.; Department of Medicine, Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Pereira AC; Million Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, Boston, MA, USA.; Department of Medicine, Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Gaziano JM; Million Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, Boston, MA, USA.; Department of Medicine, Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Cho K; Million Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, Boston, MA, USA.; Department of Medicine, Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Caruth L; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Guare L; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Kripke CM; Departments of Medicine and Biostatistics, Epidemiology & Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Rader DJ; Departments of Genetics and Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Verma SS; Department of Pathology and Laboratory Medicine and Biostatistics, Epidemiology & Informatics, Perelman School of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Verma A; Departments of Medicine and Biostatistics, Epidemiology & Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Saad C; Qatar Genome, Qatar Precision Health Institute, Qatar Foundation, Doha, Qatar., Mbarek H; Qatar Genome, Qatar Precision Health Institute, Qatar Foundation, Doha, Qatar., Chao PY; Institute of Health Data Analytics and Statistics, College of Public Health, National Taiwan University College of Public Health, Taipei City, Taiwan., Chen TT; Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan., Lin YF; Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan., Feng YA; Institute of Health Data Analytics and Statistics, College of Public Health, National Taiwan University College of Public Health, Taipei City, Taiwan.; Department of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan., Challa PK; Gastroenterology Unit, Massachusetts General Hospital, Boston, MA, USA.; Clinical Translational Epidemiology Unit, Mongan Institute, Massachusetts General Hospital, Boston, MA, USA., Khalili H; Gastroenterology Unit, Massachusetts General Hospital, Boston, MA, USA.; Clinical Translational Epidemiology Unit, Mongan Institute, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Andries A; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway., Ness-Jensen E; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.; Department of Medicine, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway.; Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden., Brumpton BM; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.; Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Grover M; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA., Lemmelä S; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.; Finnish Institute for Health and Welfare (THL), Helsinki, Finland., Sanna S; Institute for Genetics and Biomedical Research, National Research Council, Cagliari, Italy.; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Bonfiglio F; Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy.; CEINGE Biotecnologie Avanzate Franco Salvatore s.c.a r.l, Naples, Italy., D'Amato M; Department of Medicine and Surgery, LUM University, Casamassima, Italy damato@lum.it.; Gastrointestinal Genetics Lab, CIC bioGUNE - BRTA, Derio, Spain.; Ikerbasque, Basque Foundation for Science, Bilbao, Spain.
Corporate Authors: Colorado Center for Personalized Medicine, Estonian Biobank Research Team, Lifelines Cohort, Penn Medicine BioBank, FinnGen
Source: Gut [Gut] 2026 Jul 09. Date of Electronic Publication: 2026 Jul 09.
Publication Type: Journal Article
Journal Info: Publisher: British Medical Assn Country of Publication: England NLM ID: 2985108R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-3288 (Electronic) Linking ISSN: 00175749 NLM ISO Abbreviation: Gut Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1468-3288
DOI:10.1136/gutjnl-2026-338800