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Cross-definition GWAS of IBS in 2.8 million individuals reveals cardiometabolic and triglyceride-linked mechanisms.

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Title: Cross-definition GWAS of IBS in 2.8 million individuals reveals cardiometabolic and triglyceride-linked mechanisms.
Authors: Di Lorenzo B; Department of Medicine and Surgery, LUM University, Casamassima, Italy., Camargo Tavares L; National Centre for Epidemiology and Population Health, Australian National University, Canberra, Australian Capital Territory, Australia.; Hypertension Research Laboratory, Department of Pharmacology, Biomedical Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.; Gastroenterology Unit, Massachusetts General Hospital, Boston, MA, USA.; Clinical Translational Epidemiology Unit, Mongan Institute, Massachusetts General Hospital, Boston, MA, USA., Díaz-Muñoz C; Gastrointestinal Genetics Lab, CIC bioGUNE - BRTA, Derio, Spain., Heredia-Fernández F; Gastrointestinal Genetics Lab, CIC bioGUNE - BRTA, Derio, Spain., Bozzarelli I; Department of Medicine and Surgery, LUM University, Casamassima, Italy., Esteban Blanco C; Gastrointestinal Genetics Lab, CIC bioGUNE - BRTA, Derio, Spain., Wang Z; Department of Epidemiology, University of Alabama at Birmingham Health System, Birmingham, AL, USA.; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Smit RAJ; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Loos RJF; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hirbo J; Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetic Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Cox NJ; Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetic Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Straub P; Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetic Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Favé MJ; Centre for Structural and Functional Genomics, Department of Biology, Concordia University, Montréal, Quebec, Canada.; Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Awadalla P; Molecular Genetics, University of Oxford, Oxford, UK.; Big Data Institute, Nuffield Department of Health, University of Oxford, Oxford, UK., Pozdeyev N; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA.; Division of Endocrinology, Diabetes and Metabolism, University of Colorado Anschutz, Aurora, CO, USA.; Colorado Center for Personalized Medicine, University of Colorado Anschutz, Aurora, CO, USA.; University of Colorado Cancer Center, University of Colorado Anschutz, Aurora, CO, USA., Gignoux CR; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA.; Colorado Center for Personalized Medicine, University of Colorado Anschutz, Aurora, CO, USA.; University of Colorado Cancer Center, University of Colorado Anschutz, Aurora, CO, USA.; Human Medical Genetics and Genomics Program, University of Colorado Anschutz, Aurora, CO, USA., Gudbjartsson DF; Amgen deCODE Genetics, Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland., Thorleifsson G; Amgen deCODE Genetics, Reykjavik, Iceland., Jonsdottir I; Amgen deCODE Genetics, Reykjavik, Iceland.; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland., Stefansson K; Amgen deCODE Genetics, Reykjavik, Iceland.; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland., Abner E; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Palta P; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Williams AT; Division of Public Health and Epidemiology, School of Medical Sciences, University of Leicester, Leicester, UK., Coley K; Division of Public Health and Epidemiology, School of Medical Sciences, University of Leicester, Leicester, UK.; University Hospitals of Leicester NHS Trust, Leicester, UK., Sze G; Division of Public Health and Epidemiology, School of Medical Sciences, University of Leicester, Leicester, UK.; University Hospitals of Leicester NHS Trust, Leicester, UK., John C; Division of Public Health and Epidemiology, School of Medical Sciences, University of Leicester, Leicester, UK.; University Hospitals of Leicester NHS Trust, Leicester, UK., Richmond A; Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., McCartney D; Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Hayward C; Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Mulford AJ; Genomic Health Initiative, Endeavor Health, Evanston, IL, USA., Sanders AR; Genomic Health Initiative, Endeavor Health, Evanston, IL, USA.; Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, IL, USA., Peculis R; Latvian Biomedical Research and Study Centre, Riga, Latvia., Rovite V; Latvian Biomedical Research and Study Centre, Riga, Latvia., Dombrovska MS; Latvian Biomedical Research and Study Centre, Riga, Latvia., Capasso M; Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy.; CEINGE Biotecnologie Avanzate Franco Salvatore s.c.a r.l, Naples, Italy., Lo Faro V; Institute for Genetics and Biomedical Research, National Research Council, Cagliari, Italy.; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Sinha T; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Lopera Maya EA; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Zhernakova A; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Wang Y; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Martin A; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Vanderwerff B; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, University of Michigan, Ann Arbor, MI, USA., Zöllner S; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, University of Michigan, Ann Arbor, MI, USA.; Department of Psychiatry, University of Michigan School of Medicine, University of Michigan, Ann Arbor, MI, USA., Ferolito BR; Million Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, Boston, MA, USA.; Department of Medicine, Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Pereira AC; Million Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, Boston, MA, USA.; Department of Medicine, Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Gaziano JM; Million Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, Boston, MA, USA.; Department of Medicine, Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Cho K; Million Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, Boston, MA, USA.; Department of Medicine, Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Caruth L; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Guare L; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Kripke CM; Departments of Medicine and Biostatistics, Epidemiology & Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Rader DJ; Departments of Genetics and Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Verma SS; Department of Pathology and Laboratory Medicine and Biostatistics, Epidemiology & Informatics, Perelman School of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Verma A; Departments of Medicine and Biostatistics, Epidemiology & Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Saad C; Qatar Genome, Qatar Precision Health Institute, Qatar Foundation, Doha, Qatar., Mbarek H; Qatar Genome, Qatar Precision Health Institute, Qatar Foundation, Doha, Qatar., Chao PY; Institute of Health Data Analytics and Statistics, College of Public Health, National Taiwan University College of Public Health, Taipei City, Taiwan., Chen TT; Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan., Lin YF; Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan., Feng YA; Institute of Health Data Analytics and Statistics, College of Public Health, National Taiwan University College of Public Health, Taipei City, Taiwan.; Department of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan., Challa PK; Gastroenterology Unit, Massachusetts General Hospital, Boston, MA, USA.; Clinical Translational Epidemiology Unit, Mongan Institute, Massachusetts General Hospital, Boston, MA, USA., Khalili H; Gastroenterology Unit, Massachusetts General Hospital, Boston, MA, USA.; Clinical Translational Epidemiology Unit, Mongan Institute, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Andries A; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway., Ness-Jensen E; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.; Department of Medicine, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway.; Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden., Brumpton BM; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.; Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Grover M; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA., Lemmelä S; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.; Finnish Institute for Health and Welfare (THL), Helsinki, Finland., Sanna S; Institute for Genetics and Biomedical Research, National Research Council, Cagliari, Italy.; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Bonfiglio F; Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy.; CEINGE Biotecnologie Avanzate Franco Salvatore s.c.a r.l, Naples, Italy., D'Amato M; Department of Medicine and Surgery, LUM University, Casamassima, Italy damato@lum.it.; Gastrointestinal Genetics Lab, CIC bioGUNE - BRTA, Derio, Spain.; Ikerbasque, Basque Foundation for Science, Bilbao, Spain.
Corporate Authors: Colorado Center for Personalized Medicine, Estonian Biobank Research Team, Lifelines Cohort, Penn Medicine BioBank, FinnGen
Source: Gut [Gut] 2026 Jul 09. Date of Electronic Publication: 2026 Jul 09.
Publication Type: Journal Article
Journal Info: Publisher: British Medical Assn Country of Publication: England NLM ID: 2985108R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-3288 (Electronic) Linking ISSN: 00175749 NLM ISO Abbreviation: Gut Subsets: MEDLINE
Database: MEDLINE Ultimate
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Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 42425734
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Cross-definition GWAS of IBS in 2.8 million individuals reveals cardiometabolic and triglyceride-linked mechanisms.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Di+Lorenzo+B%22">Di Lorenzo B</searchLink>; Department of Medicine and Surgery, LUM University, Casamassima, Italy.<br /><searchLink fieldCode="AU" term="%22Camargo+Tavares+L%22">Camargo Tavares L</searchLink>; National Centre for Epidemiology and Population Health, Australian National University, Canberra, Australian Capital Territory, Australia.; Hypertension Research Laboratory, Department of Pharmacology, Biomedical Discovery Institute, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.; Gastroenterology Unit, Massachusetts General Hospital, Boston, MA, USA.; Clinical Translational Epidemiology Unit, Mongan Institute, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Díaz-Muñoz+C%22">Díaz-Muñoz C</searchLink>; Gastrointestinal Genetics Lab, CIC bioGUNE - BRTA, Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Heredia-Fernández+F%22">Heredia-Fernández F</searchLink>; Gastrointestinal Genetics Lab, CIC bioGUNE - BRTA, Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Bozzarelli+I%22">Bozzarelli I</searchLink>; Department of Medicine and Surgery, LUM University, Casamassima, Italy.<br /><searchLink fieldCode="AU" term="%22Esteban+Blanco+C%22">Esteban Blanco C</searchLink>; Gastrointestinal Genetics Lab, CIC bioGUNE - BRTA, Derio, Spain.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Department of Epidemiology, University of Alabama at Birmingham Health System, Birmingham, AL, USA.; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Smit+RAJ%22">Smit RAJ</searchLink>; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Loos+RJF%22">Loos RJF</searchLink>; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Hirbo+J%22">Hirbo J</searchLink>; Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetic Institute, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Cox+NJ%22">Cox NJ</searchLink>; Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetic Institute, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Straub+P%22">Straub P</searchLink>; Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Genetic Institute, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Favé+MJ%22">Favé MJ</searchLink>; Centre for Structural and Functional Genomics, Department of Biology, Concordia University, Montréal, Quebec, Canada.; Ontario Institute for Cancer Research, Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Awadalla+P%22">Awadalla P</searchLink>; Molecular Genetics, University of Oxford, Oxford, UK.; Big Data Institute, Nuffield Department of Health, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Pozdeyev+N%22">Pozdeyev N</searchLink>; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA.; Division of Endocrinology, Diabetes and Metabolism, University of Colorado Anschutz, Aurora, CO, USA.; Colorado Center for Personalized Medicine, University of Colorado Anschutz, Aurora, CO, USA.; University of Colorado Cancer Center, University of Colorado Anschutz, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Gignoux+CR%22">Gignoux CR</searchLink>; Department of Biomedical Informatics, University of Colorado Anschutz, Aurora, CO, USA.; Colorado Center for Personalized Medicine, University of Colorado Anschutz, Aurora, CO, USA.; University of Colorado Cancer Center, University of Colorado Anschutz, Aurora, CO, USA.; Human Medical Genetics and Genomics Program, University of Colorado Anschutz, Aurora, CO, USA.<br /><searchLink fieldCode="AU" term="%22Gudbjartsson+DF%22">Gudbjartsson DF</searchLink>; Amgen deCODE Genetics, Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Thorleifsson+G%22">Thorleifsson G</searchLink>; Amgen deCODE Genetics, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Jonsdottir+I%22">Jonsdottir I</searchLink>; Amgen deCODE Genetics, Reykjavik, Iceland.; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Stefansson+K%22">Stefansson K</searchLink>; Amgen deCODE Genetics, Reykjavik, Iceland.; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.<br /><searchLink fieldCode="AU" term="%22Abner+E%22">Abner E</searchLink>; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Palta+P%22">Palta P</searchLink>; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.<br /><searchLink fieldCode="AU" term="%22Williams+AT%22">Williams AT</searchLink>; Division of Public Health and Epidemiology, School of Medical Sciences, University of Leicester, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Coley+K%22">Coley K</searchLink>; Division of Public Health and Epidemiology, School of Medical Sciences, University of Leicester, Leicester, UK.; University Hospitals of Leicester NHS Trust, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Sze+G%22">Sze G</searchLink>; Division of Public Health and Epidemiology, School of Medical Sciences, University of Leicester, Leicester, UK.; University Hospitals of Leicester NHS Trust, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22John+C%22">John C</searchLink>; Division of Public Health and Epidemiology, School of Medical Sciences, University of Leicester, Leicester, UK.; University Hospitals of Leicester NHS Trust, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Richmond+A%22">Richmond A</searchLink>; Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22McCartney+D%22">McCartney D</searchLink>; Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Hayward+C%22">Hayward C</searchLink>; Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Mulford+AJ%22">Mulford AJ</searchLink>; Genomic Health Initiative, Endeavor Health, Evanston, IL, USA.<br /><searchLink fieldCode="AU" term="%22Sanders+AR%22">Sanders AR</searchLink>; Genomic Health Initiative, Endeavor Health, Evanston, IL, USA.; Department of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Peculis+R%22">Peculis R</searchLink>; Latvian Biomedical Research and Study Centre, Riga, Latvia.<br /><searchLink fieldCode="AU" term="%22Rovite+V%22">Rovite V</searchLink>; Latvian Biomedical Research and Study Centre, Riga, Latvia.<br /><searchLink fieldCode="AU" term="%22Dombrovska+MS%22">Dombrovska MS</searchLink>; Latvian Biomedical Research and Study Centre, Riga, Latvia.<br /><searchLink fieldCode="AU" term="%22Capasso+M%22">Capasso M</searchLink>; Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy.; CEINGE Biotecnologie Avanzate Franco Salvatore s.c.a r.l, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Lo+Faro+V%22">Lo Faro V</searchLink>; Institute for Genetics and Biomedical Research, National Research Council, Cagliari, Italy.; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Sinha+T%22">Sinha T</searchLink>; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Lopera+Maya+EA%22">Lopera Maya EA</searchLink>; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Zhernakova+A%22">Zhernakova A</searchLink>; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Martin+A%22">Martin A</searchLink>; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Vanderwerff+B%22">Vanderwerff B</searchLink>; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Zöllner+S%22">Zöllner S</searchLink>; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, University of Michigan, Ann Arbor, MI, USA.; Department of Psychiatry, University of Michigan School of Medicine, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Ferolito+BR%22">Ferolito BR</searchLink>; Million Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, Boston, MA, USA.; Department of Medicine, Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Pereira+AC%22">Pereira AC</searchLink>; Million Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, Boston, MA, USA.; Department of Medicine, Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gaziano+JM%22">Gaziano JM</searchLink>; Million Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, Boston, MA, USA.; Department of Medicine, Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Cho+K%22">Cho K</searchLink>; Million Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, Boston, MA, USA.; Department of Medicine, Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Caruth+L%22">Caruth L</searchLink>; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Guare+L%22">Guare L</searchLink>; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Kripke+CM%22">Kripke CM</searchLink>; Departments of Medicine and Biostatistics, Epidemiology & Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Rader+DJ%22">Rader DJ</searchLink>; Departments of Genetics and Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Verma+SS%22">Verma SS</searchLink>; Department of Pathology and Laboratory Medicine and Biostatistics, Epidemiology & Informatics, Perelman School of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Verma+A%22">Verma A</searchLink>; Departments of Medicine and Biostatistics, Epidemiology & Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Saad+C%22">Saad C</searchLink>; Qatar Genome, Qatar Precision Health Institute, Qatar Foundation, Doha, Qatar.<br /><searchLink fieldCode="AU" term="%22Mbarek+H%22">Mbarek H</searchLink>; Qatar Genome, Qatar Precision Health Institute, Qatar Foundation, Doha, Qatar.<br /><searchLink fieldCode="AU" term="%22Chao+PY%22">Chao PY</searchLink>; Institute of Health Data Analytics and Statistics, College of Public Health, National Taiwan University College of Public Health, Taipei City, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+TT%22">Chen TT</searchLink>; Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+YF%22">Lin YF</searchLink>; Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli, Taiwan.<br /><searchLink fieldCode="AU" term="%22Feng+YA%22">Feng YA</searchLink>; Institute of Health Data Analytics and Statistics, College of Public Health, National Taiwan University College of Public Health, Taipei City, Taiwan.; Department of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Challa+PK%22">Challa PK</searchLink>; Gastroenterology Unit, Massachusetts General Hospital, Boston, MA, USA.; Clinical Translational Epidemiology Unit, Mongan Institute, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Khalili+H%22">Khalili H</searchLink>; Gastroenterology Unit, Massachusetts General Hospital, Boston, MA, USA.; Clinical Translational Epidemiology Unit, Mongan Institute, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Andries+A%22">Andries A</searchLink>; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Ness-Jensen+E%22">Ness-Jensen E</searchLink>; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.; Department of Medicine, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway.; Upper Gastrointestinal Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Brumpton+BM%22">Brumpton BM</searchLink>; HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.; HUNT Research Centre, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway.; Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.<br /><searchLink fieldCode="AU" term="%22Grover+M%22">Grover M</searchLink>; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Lemmelä+S%22">Lemmelä S</searchLink>; Institute for Molecular Medicine Finland (FIMM), Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland.; Finnish Institute for Health and Welfare (THL), Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Sanna+S%22">Sanna S</searchLink>; Institute for Genetics and Biomedical Research, National Research Council, Cagliari, Italy.; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Bonfiglio+F%22">Bonfiglio F</searchLink>; Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Naples, Italy.; CEINGE Biotecnologie Avanzate Franco Salvatore s.c.a r.l, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22D'Amato+M%22">D'Amato M</searchLink>; Department of Medicine and Surgery, LUM University, Casamassima, Italy damato@lum.it.; Gastrointestinal Genetics Lab, CIC bioGUNE - BRTA, Derio, Spain.; Ikerbasque, Basque Foundation for Science, Bilbao, Spain.
– Name: AuthorCorporate
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  Data: <searchLink fieldCode="CA" term="%22Colorado+Center+for+Personalized+Medicine%22">Colorado Center for Personalized Medicine</searchLink><br /><searchLink fieldCode="CA" term="%22Estonian+Biobank+Research+Team%22">Estonian Biobank Research Team</searchLink><br /><searchLink fieldCode="CA" term="%22Lifelines+Cohort%22">Lifelines Cohort</searchLink><br /><searchLink fieldCode="CA" term="%22Penn+Medicine+BioBank%22">Penn Medicine BioBank</searchLink><br /><searchLink fieldCode="CA" term="%22FinnGen%22">FinnGen</searchLink>
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  Data: <searchLink fieldCode="JN" term="%222985108R%22">Gut</searchLink> [Gut] 2026 Jul 09. <i>Date of Electronic Publication: </i>2026 Jul 09.
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  Data: Journal Article
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22British+Medical+Assn%22">British Medical Assn </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>2985108R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1468-3288 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200175749%22">00175749 </searchLink><i>NLM ISO Abbreviation: </i>Gut <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1136/gutjnl-2026-338800
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        Text: English
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      – TitleFull: Cross-definition GWAS of IBS in 2.8 million individuals reveals cardiometabolic and triglyceride-linked mechanisms.
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            – D: 09
              M: 07
              Text: 2026 Jul 09
              Type: published
              Y: 2026
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            – Type: issn-electronic
              Value: 1468-3288
          Titles:
            – TitleFull: Gut
              Type: main
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