Single-cell analysis reveals impaired Müller glia-mediated intercellular communication and photoreceptor pathology in USH1C retinal organoids.

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Title: Single-cell analysis reveals impaired Müller glia-mediated intercellular communication and photoreceptor pathology in USH1C retinal organoids.
Authors: Wenck N; Institute of Developmental Biology and Neurobiology, Johannes Gutenberg-University Mainz, Mainz, Germany.; Institute of Molecular Physiology, Johannes Gutenberg-University Mainz, Mainz, Germany., Zorin M; Institute of Developmental Biology and Neurobiology, Johannes Gutenberg-University Mainz, Mainz, Germany.; Institute of Molecular Physiology, Johannes Gutenberg-University Mainz, Mainz, Germany., Wang Q; Institute of Physiology, University Medical Centre of Johannes Gutenberg-University Mainz, Mainz, Germany., Kröll S; Institute of Developmental Biology and Neurobiology, Johannes Gutenberg-University Mainz, Mainz, Germany.; Institute of Molecular Physiology, Johannes Gutenberg-University Mainz, Mainz, Germany., Justen A; Institute of Developmental Biology and Neurobiology, Johannes Gutenberg-University Mainz, Mainz, Germany.; Institute of Molecular Physiology, Johannes Gutenberg-University Mainz, Mainz, Germany., Hay K; Institute of Developmental Biology and Neurobiology, Johannes Gutenberg-University Mainz, Mainz, Germany.; Institute of Molecular Physiology, Johannes Gutenberg-University Mainz, Mainz, Germany., Rickert C; Light Microscopy Core Facility (LMCF) of Faculty of Biology, Johannes Gutenberg-University Mainz, Mainz, Germany., Méndez-Lago M; Institute of Molecular Biology GmbH (IMB), Mainz, Germany., Karunanithi S; Institute of Molecular Biology GmbH (IMB), Mainz, Germany., Athanasiou D; UCL Institute of Ophthalmology, University College London, London, UK., Ziaka K; UCL Institute of Ophthalmology, University College London, London, UK., De Angeli P; Institute for Ophthalmic Research, Centre for Ophthalmology, University of Tuebingen, Tuebingen, Germany., Stingl K; University Eye Hospital, Centre for Ophthalmology, University of Tuebingen, Tuebingen, Germany., Kohl S; Institute for Ophthalmic Research, Centre for Ophthalmology, University of Tuebingen, Tuebingen, Germany., Cheetham ME; UCL Institute of Ophthalmology, University College London, London, UK., Mittmann T; Institute of Physiology, University Medical Centre of Johannes Gutenberg-University Mainz, Mainz, Germany., Nagel-Wolfrum K; Institute of Developmental Biology and Neurobiology, Johannes Gutenberg-University Mainz, Mainz, Germany. nagelwol@uni-mainz.de.; Institute of Molecular Physiology, Johannes Gutenberg-University Mainz, Mainz, Germany. nagelwol@uni-mainz.de.; Institute of Quantitative and Computational Biosciences (IQCB), Johannes Gutenberg-University Mainz, Mainz, Germany. nagelwol@uni-mainz.de.
Source: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2026 Jul 09; Vol. 83 (1). Date of Electronic Publication: 2026 Jul 09.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1420-9071
DOI:10.1007/s00018-026-06321-y