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Single-cell analysis reveals impaired Müller glia-mediated intercellular communication and photoreceptor pathology in USH1C retinal organoids.

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Title: Single-cell analysis reveals impaired Müller glia-mediated intercellular communication and photoreceptor pathology in USH1C retinal organoids.
Authors: Wenck N; Institute of Developmental Biology and Neurobiology, Johannes Gutenberg-University Mainz, Mainz, Germany.; Institute of Molecular Physiology, Johannes Gutenberg-University Mainz, Mainz, Germany., Zorin M; Institute of Developmental Biology and Neurobiology, Johannes Gutenberg-University Mainz, Mainz, Germany.; Institute of Molecular Physiology, Johannes Gutenberg-University Mainz, Mainz, Germany., Wang Q; Institute of Physiology, University Medical Centre of Johannes Gutenberg-University Mainz, Mainz, Germany., Kröll S; Institute of Developmental Biology and Neurobiology, Johannes Gutenberg-University Mainz, Mainz, Germany.; Institute of Molecular Physiology, Johannes Gutenberg-University Mainz, Mainz, Germany., Justen A; Institute of Developmental Biology and Neurobiology, Johannes Gutenberg-University Mainz, Mainz, Germany.; Institute of Molecular Physiology, Johannes Gutenberg-University Mainz, Mainz, Germany., Hay K; Institute of Developmental Biology and Neurobiology, Johannes Gutenberg-University Mainz, Mainz, Germany.; Institute of Molecular Physiology, Johannes Gutenberg-University Mainz, Mainz, Germany., Rickert C; Light Microscopy Core Facility (LMCF) of Faculty of Biology, Johannes Gutenberg-University Mainz, Mainz, Germany., Méndez-Lago M; Institute of Molecular Biology GmbH (IMB), Mainz, Germany., Karunanithi S; Institute of Molecular Biology GmbH (IMB), Mainz, Germany., Athanasiou D; UCL Institute of Ophthalmology, University College London, London, UK., Ziaka K; UCL Institute of Ophthalmology, University College London, London, UK., De Angeli P; Institute for Ophthalmic Research, Centre for Ophthalmology, University of Tuebingen, Tuebingen, Germany., Stingl K; University Eye Hospital, Centre for Ophthalmology, University of Tuebingen, Tuebingen, Germany., Kohl S; Institute for Ophthalmic Research, Centre for Ophthalmology, University of Tuebingen, Tuebingen, Germany., Cheetham ME; UCL Institute of Ophthalmology, University College London, London, UK., Mittmann T; Institute of Physiology, University Medical Centre of Johannes Gutenberg-University Mainz, Mainz, Germany., Nagel-Wolfrum K; Institute of Developmental Biology and Neurobiology, Johannes Gutenberg-University Mainz, Mainz, Germany. nagelwol@uni-mainz.de.; Institute of Molecular Physiology, Johannes Gutenberg-University Mainz, Mainz, Germany. nagelwol@uni-mainz.de.; Institute of Quantitative and Computational Biosciences (IQCB), Johannes Gutenberg-University Mainz, Mainz, Germany. nagelwol@uni-mainz.de.
Source: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2026 Jul 09; Vol. 83 (1). Date of Electronic Publication: 2026 Jul 09.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Single-cell analysis reveals impaired Müller glia-mediated intercellular communication and photoreceptor pathology in USH1C retinal organoids.
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  Data: <searchLink fieldCode="AU" term="%22Wenck+N%22">Wenck N</searchLink>; Institute of Developmental Biology and Neurobiology, Johannes Gutenberg-University Mainz, Mainz, Germany.; Institute of Molecular Physiology, Johannes Gutenberg-University Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Zorin+M%22">Zorin M</searchLink>; Institute of Developmental Biology and Neurobiology, Johannes Gutenberg-University Mainz, Mainz, Germany.; Institute of Molecular Physiology, Johannes Gutenberg-University Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Wang+Q%22">Wang Q</searchLink>; Institute of Physiology, University Medical Centre of Johannes Gutenberg-University Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Kröll+S%22">Kröll S</searchLink>; Institute of Developmental Biology and Neurobiology, Johannes Gutenberg-University Mainz, Mainz, Germany.; Institute of Molecular Physiology, Johannes Gutenberg-University Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Justen+A%22">Justen A</searchLink>; Institute of Developmental Biology and Neurobiology, Johannes Gutenberg-University Mainz, Mainz, Germany.; Institute of Molecular Physiology, Johannes Gutenberg-University Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Hay+K%22">Hay K</searchLink>; Institute of Developmental Biology and Neurobiology, Johannes Gutenberg-University Mainz, Mainz, Germany.; Institute of Molecular Physiology, Johannes Gutenberg-University Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Rickert+C%22">Rickert C</searchLink>; Light Microscopy Core Facility (LMCF) of Faculty of Biology, Johannes Gutenberg-University Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Méndez-Lago+M%22">Méndez-Lago M</searchLink>; Institute of Molecular Biology GmbH (IMB), Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Karunanithi+S%22">Karunanithi S</searchLink>; Institute of Molecular Biology GmbH (IMB), Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Athanasiou+D%22">Athanasiou D</searchLink>; UCL Institute of Ophthalmology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Ziaka+K%22">Ziaka K</searchLink>; UCL Institute of Ophthalmology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22De+Angeli+P%22">De Angeli P</searchLink>; Institute for Ophthalmic Research, Centre for Ophthalmology, University of Tuebingen, Tuebingen, Germany.<br /><searchLink fieldCode="AU" term="%22Stingl+K%22">Stingl K</searchLink>; University Eye Hospital, Centre for Ophthalmology, University of Tuebingen, Tuebingen, Germany.<br /><searchLink fieldCode="AU" term="%22Kohl+S%22">Kohl S</searchLink>; Institute for Ophthalmic Research, Centre for Ophthalmology, University of Tuebingen, Tuebingen, Germany.<br /><searchLink fieldCode="AU" term="%22Cheetham+ME%22">Cheetham ME</searchLink>; UCL Institute of Ophthalmology, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Mittmann+T%22">Mittmann T</searchLink>; Institute of Physiology, University Medical Centre of Johannes Gutenberg-University Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Nagel-Wolfrum+K%22">Nagel-Wolfrum K</searchLink>; Institute of Developmental Biology and Neurobiology, Johannes Gutenberg-University Mainz, Mainz, Germany. nagelwol@uni-mainz.de.; Institute of Molecular Physiology, Johannes Gutenberg-University Mainz, Mainz, Germany. nagelwol@uni-mainz.de.; Institute of Quantitative and Computational Biosciences (IQCB), Johannes Gutenberg-University Mainz, Mainz, Germany. nagelwol@uni-mainz.de.
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  Data: <searchLink fieldCode="JN" term="%229705402%22">Cellular and molecular life sciences : CMLS</searchLink> [Cell Mol Life Sci] 2026 Jul 09; Vol. 83 (1). <i>Date of Electronic Publication: </i>2026 Jul 09.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>9705402 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1420-9071 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221420682X%22">1420682X </searchLink><i>NLM ISO Abbreviation: </i>Cell Mol Life Sci <i>Subsets: </i>MEDLINE
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      – TitleFull: Single-cell analysis reveals impaired Müller glia-mediated intercellular communication and photoreceptor pathology in USH1C retinal organoids.
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