Glycolysis-enhancing α1-adrenergic antagonists have therapeutic potential in Alzheimer's disease.

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Title: Glycolysis-enhancing α1-adrenergic antagonists have therapeutic potential in Alzheimer's disease.
Authors: Zhang Q; Department of Neurology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, 169 Newton Road, Iowa City, IA, 52242, USA. Qiang-zhang@uiowa.edu., Schultz JL; Department of Psychiatry, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA., Simmering JE; Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA., Kirkpatrick BQ; Department of Neurology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, 169 Newton Road, Iowa City, IA, 52242, USA., Weber MA; Department of Neurology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, 169 Newton Road, Iowa City, IA, 52242, USA., Skuodas S; Department of Biology, University of Iowa, Iowa City, IA, 52242, USA., Hicks T; Department of Biology, University of Iowa, Iowa City, IA, 52242, USA., Pierce G; Department of Biology, University of Iowa, Iowa City, IA, 52242, USA., Laughlin M; Department of Biology, University of Iowa, Iowa City, IA, 52242, USA., George B; Department of Neurology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, 169 Newton Road, Iowa City, IA, 52242, USA., Bertolli AX; Department of Neurology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, 169 Newton Road, Iowa City, IA, 52242, USA., Larson T; Duke Medical Scientist Training Program, Department of Neurobiology, Duke University, Durham, NC, 27710, USA., Thangavel R; Department of Neurology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, 169 Newton Road, Iowa City, IA, 52242, USA., Oya M; Johns Hopkins University, Baltimore, MD, 21205, USA., Meyerholz DK; Department of Pathology, University of Iowa, Iowa City, IA, 52242, USA., Aldridge G; Department of Neurology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, 169 Newton Road, Iowa City, IA, 52242, USA., Fassler J; Department of Biology, University of Iowa, Iowa City, IA, 52242, USA., Narayanan NS; Department of Neurology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, 169 Newton Road, Iowa City, IA, 52242, USA. Nandakumar-narayanan@uiowa.edu.
Source: Alzheimer's research & therapy [Alzheimers Res Ther] 2026 Jul 09. Date of Electronic Publication: 2026 Jul 09.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101511643 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1758-9193 (Electronic) NLM ISO Abbreviation: Alzheimers Res Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1758-9193
DOI:10.1186/s13195-026-02135-z