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Dystrophic changes of nigrostriatal axons harboring a Synj1 Parkinson mutation suggest catastrophic failure of endocytic mechanisms.

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Title: Dystrophic changes of nigrostriatal axons harboring a Synj1 Parkinson mutation suggest catastrophic failure of endocytic mechanisms.
Authors: Wu Y; Departments of Neuroscience and of Cell Biology Program in Cellular Neuroscience, Neurodegeneration, and Repair, Howard Hughes Medical Institute, Yale School of Medicine, New Haven, CT.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network., Xu P; Departments of Neuroscience and of Cell Biology Program in Cellular Neuroscience, Neurodegeneration, and Repair, Howard Hughes Medical Institute, Yale School of Medicine, New Haven, CT.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network., Moran J; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network., Xu CS; Janelia Research Campus, HHMI, Ashburn, VA 20147., Hayworth KJ; Janelia Research Campus, HHMI, Ashburn, VA 20147., Cao M; Departments of Neuroscience and of Cell Biology Program in Cellular Neuroscience, Neurodegeneration, and Repair, Howard Hughes Medical Institute, Yale School of Medicine, New Haven, CT.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network., Shao L; Center for Neurodevelopment and Plasticity, Wu Tsai Institute, Yale University, New Haven, CT,USA., Surmeier DJ; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network., Hess HF; Janelia Research Campus, HHMI, Ashburn, VA 20147., Camilli P; Departments of Neuroscience and of Cell Biology Program in Cellular Neuroscience, Neurodegeneration, and Repair, Howard Hughes Medical Institute, Yale School of Medicine, New Haven, CT.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Jun 29. Date of Electronic Publication: 2026 Jun 29.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Dystrophic changes of nigrostriatal axons harboring a Synj1 Parkinson mutation suggest catastrophic failure of endocytic mechanisms.
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  Data: <searchLink fieldCode="AU" term="%22Wu+Y%22">Wu Y</searchLink>; Departments of Neuroscience and of Cell Biology Program in Cellular Neuroscience, Neurodegeneration, and Repair, Howard Hughes Medical Institute, Yale School of Medicine, New Haven, CT.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network.<br /><searchLink fieldCode="AU" term="%22Xu+P%22">Xu P</searchLink>; Departments of Neuroscience and of Cell Biology Program in Cellular Neuroscience, Neurodegeneration, and Repair, Howard Hughes Medical Institute, Yale School of Medicine, New Haven, CT.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network.<br /><searchLink fieldCode="AU" term="%22Moran+J%22">Moran J</searchLink>; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network.<br /><searchLink fieldCode="AU" term="%22Xu+CS%22">Xu CS</searchLink>; Janelia Research Campus, HHMI, Ashburn, VA 20147.<br /><searchLink fieldCode="AU" term="%22Hayworth+KJ%22">Hayworth KJ</searchLink>; Janelia Research Campus, HHMI, Ashburn, VA 20147.<br /><searchLink fieldCode="AU" term="%22Cao+M%22">Cao M</searchLink>; Departments of Neuroscience and of Cell Biology Program in Cellular Neuroscience, Neurodegeneration, and Repair, Howard Hughes Medical Institute, Yale School of Medicine, New Haven, CT.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network.<br /><searchLink fieldCode="AU" term="%22Shao+L%22">Shao L</searchLink>; Center for Neurodevelopment and Plasticity, Wu Tsai Institute, Yale University, New Haven, CT,USA.<br /><searchLink fieldCode="AU" term="%22Surmeier+DJ%22">Surmeier DJ</searchLink>; Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network.<br /><searchLink fieldCode="AU" term="%22Hess+HF%22">Hess HF</searchLink>; Janelia Research Campus, HHMI, Ashburn, VA 20147.<br /><searchLink fieldCode="AU" term="%22Camilli+P%22">Camilli P</searchLink>; Departments of Neuroscience and of Cell Biology Program in Cellular Neuroscience, Neurodegeneration, and Repair, Howard Hughes Medical Institute, Yale School of Medicine, New Haven, CT.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network.
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  Data: <searchLink fieldCode="JN" term="%22101680187%22">BioRxiv : the preprint server for biology</searchLink> [bioRxiv] 2026 Jun 29. <i>Date of Electronic Publication: </i>2026 Jun 29.
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  Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101680187 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2692-8205 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226928205%22">26928205 </searchLink><i>NLM ISO Abbreviation: </i>bioRxiv <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.64898/2026.06.24.733515
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        Text: English
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              Text: 2026 Jun 29
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