Minute-Scale Repeated Metabolic Probing of Living Cells Enabled by Rapid Parahydrogen-Based Hyperpolarization.

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Title: Minute-Scale Repeated Metabolic Probing of Living Cells Enabled by Rapid Parahydrogen-Based Hyperpolarization.
Authors: Groß PR; Division of Medical Physics, Department of Radiology, Medical Center and Faculty of Medicine, Freiburg, Germany.; German Cancer Consortium (DKTK), Partner Site Freiburg, a Partnership Between DKFZ and University Medical Center Freiburg, Heidelberg, Germany.; Albert Ludwigs University Freiburg, Faculty of Biology, Freiburg, Germany., Petersen S; Division of Medical Physics, Department of Radiology, Medical Center and Faculty of Medicine, Freiburg, Germany., Wang Z; Division of Medical Physics, Department of Radiology, Medical Center and Faculty of Medicine, Freiburg, Germany., Shamshiri B; Division of Medical Physics, Department of Radiology, Medical Center and Faculty of Medicine, Freiburg, Germany., de Maissin H; Division of Medical Physics, Department of Radiology, Medical Center and Faculty of Medicine, Freiburg, Germany.; German Cancer Consortium (DKTK), Partner Site Freiburg, a Partnership Between DKFZ and University Medical Center Freiburg, Heidelberg, Germany., Lucas S; NVision Imaging Technologies GmbH, Ulm, Germany., Gorka O; Faculty of Medicine, Medical Center, Institute of Neuropathology, University of Freiburg, Freiburg, Germany., Heß L; Institute of Molecular Medicine and Cell Research, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Marco-Rius I; Institute For Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain., Mangas-Florencio L; Institute For Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.; University of Barcelona, Barcelona, Spain., Martins AF; Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, Eberhard Karls University Tübingen, Tübingen, Germany.; Cluster of Escellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany., Boehm-Sturm P; Charité 3R - Replace, Reduce, Refine, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Department of Experimental Neurology and Center for Stroke Research Berlin, Charité-Universitätsmedizin Berlin, Berlin, Germany.; Charité Core Facility Experimental MRIs (RRID SCR_017810), Charité - Universitätsmedizin Berlin, Berlin, Germany.; German Cancer Consortium (DKTK), Partner Site Berlin, a Partnership Between DKFZ and Charité - Universitätsmedizin Berlin, Berlin, Germany., Zaitsev M; Division of Medical Physics, Department of Radiology, Medical Center and Faculty of Medicine, Freiburg, Germany., Zeiser R; German Cancer Consortium (DKTK), Partner Site Freiburg, a Partnership Between DKFZ and University Medical Center Freiburg, Heidelberg, Germany.; Faculty of Medicine, Hematology and Oncology, Department of Medicine I, Medical Center, University of Freiburg, Freiburg, Germany.; Center For Integrative Biological Signalling Studies (CIBSS), University of Freiburg, Freiburg, Germany., Hövener JB; Sektion Biomedizinsche Bildgebung, Molecular Imaging North Competence Center MOINCC, Klinik Für Radiologie und Neuroradiologie, University Hospital Schleswig-Holstein, Kiel University, Kiel, Germany., Reinheckel T; German Cancer Consortium (DKTK), Partner Site Freiburg, a Partnership Between DKFZ and University Medical Center Freiburg, Heidelberg, Germany.; Institute of Molecular Medicine and Cell Research, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Centre for Biological Signalling Studies (BIOSS), University of Freiburg, Freiburg, Germany., Groß O; German Cancer Consortium (DKTK), Partner Site Freiburg, a Partnership Between DKFZ and University Medical Center Freiburg, Heidelberg, Germany.; Faculty of Medicine, Medical Center, Institute of Neuropathology, University of Freiburg, Freiburg, Germany.; Center For Integrative Biological Signalling Studies (CIBSS), University of Freiburg, Freiburg, Germany., Schmidt AB; Division of Medical Physics, Department of Radiology, Medical Center and Faculty of Medicine, Freiburg, Germany.; German Cancer Consortium (DKTK), Partner Site Freiburg, a Partnership Between DKFZ and University Medical Center Freiburg, Heidelberg, Germany.
Source: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2026 Jul 10, pp. e4855536. Date of Electronic Publication: 2026 Jul 10.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1521-3773
DOI:10.1002/anie.4855536