Topical medium-length PDRN enhances dermal extracellular matrix repair in photodamaged skin via PI3K-Akt/TGF-β-regulated pathways.

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Title: Topical medium-length PDRN enhances dermal extracellular matrix repair in photodamaged skin via PI3K-Akt/TGF-β-regulated pathways.
Authors: Ye R; Department of Dermatology & Venereology, Center of Cosmetic Safety and Efficacy Evaluation and NMPA Key Laboratory for Human Evaluation and Big Data of Cosmetics, West China Hospital, Sichuan University, Chengdu, China.; UNISKIN Research Institute on Skin Aging, Inertia Shanghai Biotechnology Co., Ltd., Shanghai, China.; DermaHealth Shanghai Biotechnology Co., Ltd., Shanghai, China., Wang Q; Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China., Du L; UNISKIN Research Institute on Skin Aging, Inertia Shanghai Biotechnology Co., Ltd., Shanghai, China.; DermaHealth Shanghai Biotechnology Co., Ltd., Shanghai, China., Li L; Department of Dermatology & Venereology, Center of Cosmetic Safety and Efficacy Evaluation and NMPA Key Laboratory for Human Evaluation and Big Data of Cosmetics, West China Hospital, Sichuan University, Chengdu, China., Hu F; UNISKIN Research Institute on Skin Aging, Inertia Shanghai Biotechnology Co., Ltd., Shanghai, China.; DermaHealth Shanghai Biotechnology Co., Ltd., Shanghai, China.
Source: PloS one [PLoS One] 2026 Jul 10; Vol. 21 (7), pp. e0350905. Date of Electronic Publication: 2026 Jul 10 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1932-6203
DOI:10.1371/journal.pone.0350905