A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing.

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Title: A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing.
Authors: Wang H; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK., Mennea PD; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK., McAndrew G; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK., Sonmezler O; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK., Shcherbo DS; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK., Ditter EJ; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK., Jensen SØ; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK., Buma AIG; Department of Respiratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands., Smith CG; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK., Cheng Z; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK., Harris C; Victor Philip Dahdaleh Heart and Lung Research Institute, Department of Medicine, University of Cambridge, Cambridge CB2 0BB, UK., Cutts RJ; Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London SW3 6JB, UK., Hrebien S; Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London SW3 6JB, UK., Crosbie PAJ; Division of Immunology, Immunity to Infection and Respiratory Medicine, Faculty of Biology Medicine and Health, University of Manchester, Manchester M13 9PT, UK., Corrie PG; Department of Oncology, Cambridge University Hospitals NHS Trust, Cambridge CB2 0QQ, UK., van den Heuvel MM; Department of Respiratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands.; Department of Respiratory Medicine, University Medical Center Utrecht, Utrecht, Netherlands., Roshan A; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK.; Department of Plastic & Reconstructive Surgery, Cambridge University Hospitals NHS Trust, Cambridge CB2 0QQ, UK., McCaughan F; Victor Philip Dahdaleh Heart and Lung Research Institute, Department of Medicine, University of Cambridge, Cambridge CB2 0BB, UK., Rintoul RC; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK.; Royal Papworth Hospital NHS Foundation Trust, Cambridge CB2 0AY, UK.; Department of Oncology, University of Cambridge, Cambridge CB2 0QQ, UK., Markowetz F; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK., Kaplan T; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK.; School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel.; Department of Developmental Biology and Cancer Research, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel., Cooper WN; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK., Zhao H; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK., Rosenfeld N; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK.
Source: Science advances [Sci Adv] 2026 Jul 10; Vol. 12 (28), pp. eady9432. Date of Electronic Publication: 2026 Jul 10.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2375-2548
DOI:10.1126/sciadv.ady9432