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A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing.

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Title: A scalable deep-learning framework for cancer detection using cell-free DNA shallow whole-genome sequencing.
Authors: Wang H; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK., Mennea PD; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK., McAndrew G; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK., Sonmezler O; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK., Shcherbo DS; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK., Ditter EJ; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK., Jensen SØ; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK., Buma AIG; Department of Respiratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands., Smith CG; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK., Cheng Z; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK., Harris C; Victor Philip Dahdaleh Heart and Lung Research Institute, Department of Medicine, University of Cambridge, Cambridge CB2 0BB, UK., Cutts RJ; Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London SW3 6JB, UK., Hrebien S; Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London SW3 6JB, UK., Crosbie PAJ; Division of Immunology, Immunity to Infection and Respiratory Medicine, Faculty of Biology Medicine and Health, University of Manchester, Manchester M13 9PT, UK., Corrie PG; Department of Oncology, Cambridge University Hospitals NHS Trust, Cambridge CB2 0QQ, UK., van den Heuvel MM; Department of Respiratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands.; Department of Respiratory Medicine, University Medical Center Utrecht, Utrecht, Netherlands., Roshan A; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK.; Department of Plastic & Reconstructive Surgery, Cambridge University Hospitals NHS Trust, Cambridge CB2 0QQ, UK., McCaughan F; Victor Philip Dahdaleh Heart and Lung Research Institute, Department of Medicine, University of Cambridge, Cambridge CB2 0BB, UK., Rintoul RC; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK.; Royal Papworth Hospital NHS Foundation Trust, Cambridge CB2 0AY, UK.; Department of Oncology, University of Cambridge, Cambridge CB2 0QQ, UK., Markowetz F; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK., Kaplan T; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK.; School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel.; Department of Developmental Biology and Cancer Research, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel., Cooper WN; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK., Zhao H; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK., Rosenfeld N; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK.
Source: Science advances [Sci Adv] 2026 Jul 10; Vol. 12 (28), pp. eady9432. Date of Electronic Publication: 2026 Jul 10.
Publication Type: Journal Article
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  Data: <searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK.<br /><searchLink fieldCode="AU" term="%22Mennea+PD%22">Mennea PD</searchLink>; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK.<br /><searchLink fieldCode="AU" term="%22McAndrew+G%22">McAndrew G</searchLink>; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK.<br /><searchLink fieldCode="AU" term="%22Sonmezler+O%22">Sonmezler O</searchLink>; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK.<br /><searchLink fieldCode="AU" term="%22Shcherbo+DS%22">Shcherbo DS</searchLink>; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK.<br /><searchLink fieldCode="AU" term="%22Ditter+EJ%22">Ditter EJ</searchLink>; 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Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK.<br /><searchLink fieldCode="AU" term="%22Harris+C%22">Harris C</searchLink>; Victor Philip Dahdaleh Heart and Lung Research Institute, Department of Medicine, University of Cambridge, Cambridge CB2 0BB, UK.<br /><searchLink fieldCode="AU" term="%22Cutts+RJ%22">Cutts RJ</searchLink>; Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.<br /><searchLink fieldCode="AU" term="%22Hrebien+S%22">Hrebien S</searchLink>; Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London SW3 6JB, UK.<br /><searchLink fieldCode="AU" term="%22Crosbie+PAJ%22">Crosbie PAJ</searchLink>; Division of Immunology, Immunity to Infection and Respiratory Medicine, Faculty of Biology Medicine and Health, University of Manchester, Manchester M13 9PT, UK.<br /><searchLink fieldCode="AU" term="%22Corrie+PG%22">Corrie PG</searchLink>; Department of Oncology, Cambridge University Hospitals NHS Trust, Cambridge CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22van+den+Heuvel+MM%22">van den Heuvel MM</searchLink>; Department of Respiratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands.; Department of Respiratory Medicine, University Medical Center Utrecht, Utrecht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Roshan+A%22">Roshan A</searchLink>; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK.; Department of Plastic & Reconstructive Surgery, Cambridge University Hospitals NHS Trust, Cambridge CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22McCaughan+F%22">McCaughan F</searchLink>; Victor Philip Dahdaleh Heart and Lung Research Institute, Department of Medicine, University of Cambridge, Cambridge CB2 0BB, UK.<br /><searchLink fieldCode="AU" term="%22Rintoul+RC%22">Rintoul RC</searchLink>; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK.; Royal Papworth Hospital NHS Foundation Trust, Cambridge CB2 0AY, UK.; Department of Oncology, University of Cambridge, Cambridge CB2 0QQ, UK.<br /><searchLink fieldCode="AU" term="%22Markowetz+F%22">Markowetz F</searchLink>; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK.<br /><searchLink fieldCode="AU" term="%22Kaplan+T%22">Kaplan T</searchLink>; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK.; School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem, Israel.; Department of Developmental Biology and Cancer Research, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Cooper+WN%22">Cooper WN</searchLink>; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK.<br /><searchLink fieldCode="AU" term="%22Zhao+H%22">Zhao H</searchLink>; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK.<br /><searchLink fieldCode="AU" term="%22Rosenfeld+N%22">Rosenfeld N</searchLink>; Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London EC1M 6BQ, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.; Cancer Research UK Cambridge Centre, University of Cambridge, Cambridge CB2 0RE, UK.
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