First-in-human phase I study of hypoxia-targeting 64Cu-ATSM radioligand therapy in patients with malignant brain tumors (STAR-64).

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Title: First-in-human phase I study of hypoxia-targeting 64Cu-ATSM radioligand therapy in patients with malignant brain tumors (STAR-64).
Authors: Kurihara H; Diagnostic and Interventional Radiology, Kanagawa Cancer Center Hospital, Yokohama, Japan. Electronic address: kurihara.0420j@kanagawa-pho.jp., Narita Y; Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, Tokyo, Japan., Ito K; Diagnostic Radiology, National Cancer Center Hospital, Tokyo, Japan., Sato H; Neurosurgery, Kanagawa Cancer Center Hospital, Yokohama, Japan., Miyakita Y; Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, Tokyo, Japan., Takahashi M; Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, Tokyo, Japan., Ohno M; Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, Tokyo, Japan., Yanagisawa S; Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, Tokyo, Japan., Okita NT; Clinical Research Support Office, National Cancer Center Hospital, Tokyo, Japan., Sadachi R; Clinical Research Support Office, National Cancer Center Hospital, Tokyo, Japan., Machida R; Clinical Research Support Office, National Cancer Center Hospital, Tokyo, Japan., Tateishi K; Neurosurgery, Yokohama City University, Yokohama, Japan., Yoshii Y; LinqMed Inc., Tokyo, Japan. Electronic address: yoshii.yukie@linqmed.co.jp., Waki A; National Institutes for Quantum Science and Technology, Chiba, Japan., Hashimoto H; National Institutes for Quantum Science and Technology, Chiba, Japan., Suzuki H; National Institutes for Quantum Science and Technology, Chiba, Japan., Zhang MR; National Institutes for Quantum Science and Technology, Chiba, Japan., Kawamura K; National Institutes for Quantum Science and Technology, Chiba, Japan., Honda N; Pharmacy, National Cancer Center Hospital, Tokyo, Japan., Yoshimoto M; Exploratory Oncology Research & Clinical Trial Center, National Cancer Center East, Chiba, Japan., Matsumoto H; Isotope Science Center, The University of Tokyo, Tokyo, Japan.
Source: ESMO open [ESMO Open] 2026 Jul 10; Vol. 11 (8), pp. 108249. Date of Electronic Publication: 2026 Jul 10.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101690685 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2059-7029 (Electronic) Linking ISSN: 20597029 NLM ISO Abbreviation: ESMO Open Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2059-7029
DOI:10.1016/j.esmoop.2026.108249