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Age-independent immune subtypes in type 1 diabetes exhibit distinct post-onset progression rates and immunotherapeutic responses.

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Title: Age-independent immune subtypes in type 1 diabetes exhibit distinct post-onset progression rates and immunotherapeutic responses.
Authors: Bedrat A; The Max McGee Research Center for Juvenile Diabetes, Children's Research Institute of Children's Hospital of Wisconsin, Milwaukee, WI, USA.; Department of Pediatrics, The Medical College of Wisconsin, Milwaukee, WI, USA., Truchan NA; The Max McGee Research Center for Juvenile Diabetes, Children's Research Institute of Children's Hospital of Wisconsin, Milwaukee, WI, USA.; Department of Pediatrics, The Medical College of Wisconsin, Milwaukee, WI, USA., Pant T; The Max McGee Research Center for Juvenile Diabetes, Children's Research Institute of Children's Hospital of Wisconsin, Milwaukee, WI, USA.; Department of Pediatrics, The Medical College of Wisconsin, Milwaukee, WI, USA., Jia S; The Max McGee Research Center for Juvenile Diabetes, Children's Research Institute of Children's Hospital of Wisconsin, Milwaukee, WI, USA.; Department of Pediatrics, The Medical College of Wisconsin, Milwaukee, WI, USA., Roethle MF; The Max McGee Research Center for Juvenile Diabetes, Children's Research Institute of Children's Hospital of Wisconsin, Milwaukee, WI, USA.; Department of Pediatrics, The Medical College of Wisconsin, Milwaukee, WI, USA., Chen YG; The Max McGee Research Center for Juvenile Diabetes, Children's Research Institute of Children's Hospital of Wisconsin, Milwaukee, WI, USA.; Department of Pediatrics, The Medical College of Wisconsin, Milwaukee, WI, USA., Lin CW; Division of Biostatistics, Data Science Institute, The Medical College of Wisconsin, Milwaukee, WI, USA., Hessner MJ; The Max McGee Research Center for Juvenile Diabetes, Children's Research Institute of Children's Hospital of Wisconsin, Milwaukee, WI, USA. mhessner@mcw.edu.; Department of Pediatrics, The Medical College of Wisconsin, Milwaukee, WI, USA. mhessner@mcw.edu.
Source: Diabetologia [Diabetologia] 2026 Jul 11. Date of Electronic Publication: 2026 Jul 11.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0428 (Electronic) Linking ISSN: 0012186X NLM ISO Abbreviation: Diabetologia Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Age-independent immune subtypes in type 1 diabetes exhibit distinct post-onset progression rates and immunotherapeutic responses.
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  Data: <searchLink fieldCode="AU" term="%22Bedrat+A%22">Bedrat A</searchLink>; The Max McGee Research Center for Juvenile Diabetes, Children's Research Institute of Children's Hospital of Wisconsin, Milwaukee, WI, USA.; Department of Pediatrics, The Medical College of Wisconsin, Milwaukee, WI, USA.<br /><searchLink fieldCode="AU" term="%22Truchan+NA%22">Truchan NA</searchLink>; The Max McGee Research Center for Juvenile Diabetes, Children's Research Institute of Children's Hospital of Wisconsin, Milwaukee, WI, USA.; Department of Pediatrics, The Medical College of Wisconsin, Milwaukee, WI, USA.<br /><searchLink fieldCode="AU" term="%22Pant+T%22">Pant T</searchLink>; The Max McGee Research Center for Juvenile Diabetes, Children's Research Institute of Children's Hospital of Wisconsin, Milwaukee, WI, USA.; Department of Pediatrics, The Medical College of Wisconsin, Milwaukee, WI, USA.<br /><searchLink fieldCode="AU" term="%22Jia+S%22">Jia S</searchLink>; The Max McGee Research Center for Juvenile Diabetes, Children's Research Institute of Children's Hospital of Wisconsin, Milwaukee, WI, USA.; Department of Pediatrics, The Medical College of Wisconsin, Milwaukee, WI, USA.<br /><searchLink fieldCode="AU" term="%22Roethle+MF%22">Roethle MF</searchLink>; The Max McGee Research Center for Juvenile Diabetes, Children's Research Institute of Children's Hospital of Wisconsin, Milwaukee, WI, USA.; Department of Pediatrics, The Medical College of Wisconsin, Milwaukee, WI, USA.<br /><searchLink fieldCode="AU" term="%22Chen+YG%22">Chen YG</searchLink>; The Max McGee Research Center for Juvenile Diabetes, Children's Research Institute of Children's Hospital of Wisconsin, Milwaukee, WI, USA.; Department of Pediatrics, The Medical College of Wisconsin, Milwaukee, WI, USA.<br /><searchLink fieldCode="AU" term="%22Lin+CW%22">Lin CW</searchLink>; Division of Biostatistics, Data Science Institute, The Medical College of Wisconsin, Milwaukee, WI, USA.<br /><searchLink fieldCode="AU" term="%22Hessner+MJ%22">Hessner MJ</searchLink>; The Max McGee Research Center for Juvenile Diabetes, Children's Research Institute of Children's Hospital of Wisconsin, Milwaukee, WI, USA. mhessner@mcw.edu.; Department of Pediatrics, The Medical College of Wisconsin, Milwaukee, WI, USA. mhessner@mcw.edu.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Verlag%22">Springer Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>0006777 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-0428 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220012186X%22">0012186X </searchLink><i>NLM ISO Abbreviation: </i>Diabetologia <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s00125-026-06794-3
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        Text: English
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              Text: 2026 Jul 11
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