Safety and preliminary efficacy of autologous bone marrow-derived mesenchymal stem cell transplantation in hereditary cerebellar ataxia: phase I/IIa clinical trial.

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Title: Safety and preliminary efficacy of autologous bone marrow-derived mesenchymal stem cell transplantation in hereditary cerebellar ataxia: phase I/IIa clinical trial.
Authors: Moghaddam AS; Immunology Research Center, Department of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Tavakol-Afshari J; Immunology Research Center, Department of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Farkhad NK; Immunology Research Center, Department of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Mojarrad M; Department of Medical Genetics and Molecular Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Eslami M; Applied Biotechnology Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.; International Faculty, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.; Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran., Savad S; Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran., Khodadoust MA; Immunology Research Center, Department of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Orafaie A; Endoscopic and Minimally Invasive Surgery Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran., Sobhani M; Department of Neurology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Farmanbar A; Immunology Research Center, Department of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Dashtkoohi M; International Center for Personalized Medicine (P7Medicine), 40235, Düsseldorf, Germany., Khodayari H; International Center for Personalized Medicine (P7Medicine), 40235, Düsseldorf, Germany., Hassani D; Applied Biotechnology Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran., Najafi S; Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran., Najafi P; Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran., Hescheler J; European Center for Personalized Medicine, Medical Center, European Cell Medicine Institute, Düsseldorf, Germany., Nayernia K; International Center for Personalized Medicine (P7Medicine), 40235, Düsseldorf, Germany. Nayernia@icpm.center., Boroumand A; Immunology Research Center, Department of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. arboroumand.ab@gmail.com.; International Center for Personalized Medicine (P7Medicine), 40235, Düsseldorf, Germany. arboroumand.ab@gmail.com.
Source: Stem cell research & therapy [Stem Cell Res Ther] 2026 Jul 10; Vol. 17 (1). Date of Electronic Publication: 2026 Jul 10.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101527581 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-6512 (Electronic) Linking ISSN: 17576512 NLM ISO Abbreviation: Stem Cell Res Ther Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
Description
ISSN:1757-6512
DOI:10.1186/s13287-026-05163-6