Implementing a Multi-Ancestry Polygenic Risk Score for Coronary Heart Disease in a Diverse Cohort.

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Title: Implementing a Multi-Ancestry Polygenic Risk Score for Coronary Heart Disease in a Diverse Cohort.
Authors: Hamed M; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA., Naderian M; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA., Bangash H; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA., Hernandez V; Mountain Park Health Center, Phoenix, AZ, USA., Shaibi GQ; Center for Health Promotion and Disease Prevention, Arizona State University, Phoenix, AZ, USA., Arslan M; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA., Saadatagah S; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA., Sherafati A; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA., Miller A; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA., Kamzabek A; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA., Ogunsan O; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA., Goff B; Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Davis B; Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Prows C; Divisions of Human Genetics and Patient Services, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Cimino JJ; Department of Biomedical Informatics and Data Science, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Cortopassi J; Department of Biomedical Informatics and Data Science, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Kottyan L; Divisions of Human Genetics and Patient Services, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Beasley M; Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA., Limdi N; Department of Biomedical Informatics and Data Science, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Feng Q; Department of Biomedical Informatics and Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Rowley R; National Human Genome Research Institute, Division of Genomic Medicine, Bethesda, MD, USA., Wood S; The Center for Autoimmune Genomics and Etiology, Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Wei WQ; Department of Biomedical Informatics and Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Luo Y; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Manolio TA; National Human Genome Research Institute, Division of Genomic Medicine, Bethesda, MD, USA., Schaid D; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA., Caraballo PJ; Department of Medicine, Mayo Clinic, Rochester, MN, USA., Freimuth R; Department of Artificial Intelligence and Informatics, Mayo Clinic, Rochester, MN, USA; Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA., Sharp RR; Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA; Biomedical Ethics Research Program, Mayo Clinic, Rochester, MN, USA., Kullo IJ; Division of Cardiovascular Medicine, the Cardiovascular Research Center and the Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, USA. Electronic address: ikullo@mcw.edu.
Source: Genetics in medicine : official journal of the American College of Medical Genetics [Genet Med] 2026 Jul 11, pp. 102662. Date of Electronic Publication: 2026 Jul 11.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 9815831 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0366 (Electronic) Linking ISSN: 10983600 NLM ISO Abbreviation: Genet Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1530-0366
DOI:10.1016/j.gim.2026.102662