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Implementing a Multi-Ancestry Polygenic Risk Score for Coronary Heart Disease in a Diverse Cohort.

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Title: Implementing a Multi-Ancestry Polygenic Risk Score for Coronary Heart Disease in a Diverse Cohort.
Authors: Hamed M; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA., Naderian M; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA., Bangash H; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA., Hernandez V; Mountain Park Health Center, Phoenix, AZ, USA., Shaibi GQ; Center for Health Promotion and Disease Prevention, Arizona State University, Phoenix, AZ, USA., Arslan M; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA., Saadatagah S; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA., Sherafati A; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA., Miller A; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA., Kamzabek A; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA., Ogunsan O; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA., Goff B; Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Davis B; Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Prows C; Divisions of Human Genetics and Patient Services, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Cimino JJ; Department of Biomedical Informatics and Data Science, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Cortopassi J; Department of Biomedical Informatics and Data Science, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Kottyan L; Divisions of Human Genetics and Patient Services, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Beasley M; Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA., Limdi N; Department of Biomedical Informatics and Data Science, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Feng Q; Department of Biomedical Informatics and Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Rowley R; National Human Genome Research Institute, Division of Genomic Medicine, Bethesda, MD, USA., Wood S; The Center for Autoimmune Genomics and Etiology, Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Wei WQ; Department of Biomedical Informatics and Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Luo Y; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Manolio TA; National Human Genome Research Institute, Division of Genomic Medicine, Bethesda, MD, USA., Schaid D; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA., Caraballo PJ; Department of Medicine, Mayo Clinic, Rochester, MN, USA., Freimuth R; Department of Artificial Intelligence and Informatics, Mayo Clinic, Rochester, MN, USA; Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA., Sharp RR; Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA; Biomedical Ethics Research Program, Mayo Clinic, Rochester, MN, USA., Kullo IJ; Division of Cardiovascular Medicine, the Cardiovascular Research Center and the Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, USA. Electronic address: ikullo@mcw.edu.
Source: Genetics in medicine : official journal of the American College of Medical Genetics [Genet Med] 2026 Jul 11, pp. 102662. Date of Electronic Publication: 2026 Jul 11.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 9815831 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0366 (Electronic) Linking ISSN: 10983600 NLM ISO Abbreviation: Genet Med Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Hamed+M%22">Hamed M</searchLink>; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Naderian+M%22">Naderian M</searchLink>; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Bangash+H%22">Bangash H</searchLink>; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Hernandez+V%22">Hernandez V</searchLink>; Mountain Park Health Center, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Shaibi+GQ%22">Shaibi GQ</searchLink>; Center for Health Promotion and Disease Prevention, Arizona State University, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Arslan+M%22">Arslan M</searchLink>; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Saadatagah+S%22">Saadatagah S</searchLink>; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Sherafati+A%22">Sherafati A</searchLink>; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Miller+A%22">Miller A</searchLink>; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Kamzabek+A%22">Kamzabek A</searchLink>; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Ogunsan+O%22">Ogunsan O</searchLink>; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Goff+B%22">Goff B</searchLink>; Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Davis+B%22">Davis B</searchLink>; Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Prows+C%22">Prows C</searchLink>; Divisions of Human Genetics and Patient Services, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Cimino+JJ%22">Cimino JJ</searchLink>; Department of Biomedical Informatics and Data Science, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Cortopassi+J%22">Cortopassi J</searchLink>; Department of Biomedical Informatics and Data Science, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Kottyan+L%22">Kottyan L</searchLink>; Divisions of Human Genetics and Patient Services, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Beasley+M%22">Beasley M</searchLink>; Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Limdi+N%22">Limdi N</searchLink>; Department of Biomedical Informatics and Data Science, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Feng+Q%22">Feng Q</searchLink>; Department of Biomedical Informatics and Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Rowley+R%22">Rowley R</searchLink>; National Human Genome Research Institute, Division of Genomic Medicine, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Wood+S%22">Wood S</searchLink>; The Center for Autoimmune Genomics and Etiology, Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.<br /><searchLink fieldCode="AU" term="%22Wei+WQ%22">Wei WQ</searchLink>; Department of Biomedical Informatics and Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Luo+Y%22">Luo Y</searchLink>; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Manolio+TA%22">Manolio TA</searchLink>; National Human Genome Research Institute, Division of Genomic Medicine, Bethesda, MD, USA.<br /><searchLink fieldCode="AU" term="%22Schaid+D%22">Schaid D</searchLink>; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Caraballo+PJ%22">Caraballo PJ</searchLink>; Department of Medicine, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Freimuth+R%22">Freimuth R</searchLink>; Department of Artificial Intelligence and Informatics, Mayo Clinic, Rochester, MN, USA; Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Sharp+RR%22">Sharp RR</searchLink>; Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA; Biomedical Ethics Research Program, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Kullo+IJ%22">Kullo IJ</searchLink>; Division of Cardiovascular Medicine, the Cardiovascular Research Center and the Mellowes Center for Genomic Sciences and Precision Medicine, Medical College of Wisconsin, Milwaukee, WI, USA. Electronic address: ikullo@mcw.edu.
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