Sebetralstat for breakthrough attacks in patients with hereditary angioedema receiving long-term prophylaxis in KONFIDENT-S.

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Title: Sebetralstat for breakthrough attacks in patients with hereditary angioedema receiving long-term prophylaxis in KONFIDENT-S.
Authors: Kinaciyan T; Department of Dermatology, ACARE and Hereditary Angioedema Center Vienna and Burgenland, Medical University of Vienna, Vienna, Austria., Aygören-Pürsün E; University Hospital Frankfurt, Goethe University, Frankfurt, Germany., Martinez-Saguer I; HZRM Haemophilia Center Rhein Main, Frankfurt, Germany., Soteres DF; Asthma & Allergy Associates PC, Colorado Springs, Colo., Honda D; Department of Nephrology, Graduate School of Medicine, Chiba University, Chiba, Japan., Manning ME; Department of Internal Medicine, UA College of Medicine, Phoenix, Ariz., Wedner HJ; Washington University School of Medicine, St Louis, Mo., Fukunaga A; Department of Dermatology/OMPU Allergy Center, Division of Medicine for Function and Morphology of Sensory Organs, Faculty of Medicine, Osaka Medical and Pharmaceutical University, Osaka, Japan., Kanarek HJ; Kanarek Adult & Pediatric Allergy, Asthma & Immunology, Overland Park, Kan., Ohmura K; Institute of Preventive Medical Sciences, Health Sciences University of Hokkaido, Sapporo, Japan., Melamed I; IMMUNOe Research Center, Centennial, Colo., El-Shanawany T; Department of Immunology, University Hospital of Wales, Cardiff, United Kingdom., Bouillet L; University of Grenoble Alpes, T-RAIG Unit, CNRS, UMR 5525, CHU Grenoble Alpes, TIMC, Grenoble, France.; French National Reference Center for Angioedema (CREAK), Internal Medicine Department, Grenoble University Hospital, Grenoble, France., Lumry WR; AARA Research Center, Dallas, Tex., Riedl MA; University of California-San Diego, La Jolla, Calif., Koleilat M; Deaconess Clinic, Evansville, Ind., Geng B; Allergy Asthma Medical Group & Research Center (AAMGRC), San Diego, Calif., Ohsawa I; Department of Nephrology, Saiyu Soka Hospital, Saitama, Japan., Bara N; Hereditary Angioedema Expertise Center, Sangeorgiu de Mures, Romania.; Mediquest Clinical Research Center, Sangeorgiu de Mures, Romania., Rehman S; Toledo Institute of Clinical Research, Toledo, Ohio., Bernstein JA; University of Cincinnati College of Medicine and Bernstein Clinical Research Center, Cincinnati, Ohio., Busse PJ; Division of Allergy and Clinical Immunology, Icahn School of Medicine at Mount Sinai, New York, NY., Cancian M; Departmental Allergy Division, Department of Systems Medicine, University of Padua, Padua, Italy., Cohn DM; Department of Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands., Craig TJ; Department of Medicine, Pediatrics, MFM and Biomedical Sciences, Penn State University, Hershey, Pa.; Vinmec-VinUni Institute of Immunology, Vin University, Hanoi, Vietnam.; Center of Allergy and Clinical Immunology, Vinmec Times City Hospital, Hanoi, Vietnam., Farkas H; Hungarian Angioedema Center of Reference and Excellence, Department of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary., Kiani-Alikhan S; Division of Infection and Immunity, University College London, Royal Free London NHS Foundation Trust, London, United Kingdom., Li HH; Institute for Asthma and Allergy, Wheaton, Md., Raasch JP; Midwest Immunology Clinic, Plymouth, Minn., Tachdjian R; Division of Allergy and Clinical Immunology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, Calif.; Allergy and Immunology, Providence Saint John's Health Center, Santa Monica, Calif., Audhya PK; KalVista Pharmaceuticals, Framingham, Mass., Bajcic P; KalVista Pharmaceuticals, Framingham, Mass., Chuang YH; KalVista Pharmaceuticals, Framingham, Mass., Iverson M; KalVista Pharmaceuticals, Framingham, Mass., Smith MD; KalVista Pharmaceuticals, Framingham, Mass., Yea CM; KalVista Pharmaceuticals, Framingham, Mass., Zanichelli A; Operative Unit of Medicine, Angioedema Center, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.; Dipartimento di Scienze Biomediche per la Salute, University of Milan, Milan, Italy.
Source: The journal of allergy and clinical immunology. Global [J Allergy Clin Immunol Glob] 2026 Jun 12; Vol. 5 (5), pp. 100750. Date of Electronic Publication: 2026 Jun 12 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 9918453488706676 Publication Model: eCollection Cited Medium: Internet ISSN: 2772-8293 (Electronic) Linking ISSN: 27728293 NLM ISO Abbreviation: J Allergy Clin Immunol Glob Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2772-8293
DOI:10.1016/j.jacig.2026.100750