Biological limits of lifespan extension: evidence for a shift from pathway leverage to system-level buffering across species.

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Title: Biological limits of lifespan extension: evidence for a shift from pathway leverage to system-level buffering across species.
Authors: Pirscoveanu DF; Chair of Vascular Neurology and Dementia, Department of Neurology, University Hospital Essen, Essen 45147, Germany; Department of Neurology, University of Medicine and Pharmacy Craiova, Romania., Papa MC; Department of Neurology, University of Medicine and Pharmacy Craiova, Romania., Kaltwasser B; Chair of Vascular Neurology and Dementia, Department of Neurology, University Hospital Essen, Essen 45147, Germany., Hermann DM; Chair of Vascular Neurology and Dementia, Department of Neurology, University Hospital Essen, Essen 45147, Germany; Department of Neurology, University of Medicine and Pharmacy Craiova, Romania., Brockmeier U; Chair of Vascular Neurology and Dementia, Department of Neurology, University Hospital Essen, Essen 45147, Germany., Cercel A; Chair of Vascular Neurology and Dementia, Department of Neurology, University Hospital Essen, Essen 45147, Germany; Department of Neurology, University of Medicine and Pharmacy Craiova, Romania., Oliver A; Ravan Bio Ltd, Unit 7A, Kilburn House, Lloyd St North, Manchester, M15 6SE, UK., Gruillari J; Ludwig Boltzmann Institute for Traumatology, Research Center in cooperation with AUVA, Vienna, Austria; Austrian Cluster for Tissue Regeneration, Vienna, Austria; Institute of Molecular Biotechnology, BOKU - University, Vienna, Austria., Ionica MV; Chair of Vascular Neurology and Dementia, Department of Neurology, University Hospital Essen, Essen 45147, Germany; Department of Neurology, University of Medicine and Pharmacy Craiova, Romania. Electronic address: mionica2@yahoo.com., Popa-Wagner A; Chair of Vascular Neurology and Dementia, Department of Neurology, University Hospital Essen, Essen 45147, Germany; Department of Neurology, University of Medicine and Pharmacy Craiova, Romania. Electronic address: aurel.popa-wagner@geriatrics-healthyageing.com.
Source: Mechanisms of ageing and development [Mech Ageing Dev] 2026 Jul 12, pp. 112231. Date of Electronic Publication: 2026 Jul 12.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 0347227 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6216 (Electronic) Linking ISSN: 00476374 NLM ISO Abbreviation: Mech Ageing Dev Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1872-6216
DOI:10.1016/j.mad.2026.112231