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Biological limits of lifespan extension: evidence for a shift from pathway leverage to system-level buffering across species.

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Title: Biological limits of lifespan extension: evidence for a shift from pathway leverage to system-level buffering across species.
Authors: Pirscoveanu DF; Chair of Vascular Neurology and Dementia, Department of Neurology, University Hospital Essen, Essen 45147, Germany; Department of Neurology, University of Medicine and Pharmacy Craiova, Romania., Papa MC; Department of Neurology, University of Medicine and Pharmacy Craiova, Romania., Kaltwasser B; Chair of Vascular Neurology and Dementia, Department of Neurology, University Hospital Essen, Essen 45147, Germany., Hermann DM; Chair of Vascular Neurology and Dementia, Department of Neurology, University Hospital Essen, Essen 45147, Germany; Department of Neurology, University of Medicine and Pharmacy Craiova, Romania., Brockmeier U; Chair of Vascular Neurology and Dementia, Department of Neurology, University Hospital Essen, Essen 45147, Germany., Cercel A; Chair of Vascular Neurology and Dementia, Department of Neurology, University Hospital Essen, Essen 45147, Germany; Department of Neurology, University of Medicine and Pharmacy Craiova, Romania., Oliver A; Ravan Bio Ltd, Unit 7A, Kilburn House, Lloyd St North, Manchester, M15 6SE, UK., Gruillari J; Ludwig Boltzmann Institute for Traumatology, Research Center in cooperation with AUVA, Vienna, Austria; Austrian Cluster for Tissue Regeneration, Vienna, Austria; Institute of Molecular Biotechnology, BOKU - University, Vienna, Austria., Ionica MV; Chair of Vascular Neurology and Dementia, Department of Neurology, University Hospital Essen, Essen 45147, Germany; Department of Neurology, University of Medicine and Pharmacy Craiova, Romania. Electronic address: mionica2@yahoo.com., Popa-Wagner A; Chair of Vascular Neurology and Dementia, Department of Neurology, University Hospital Essen, Essen 45147, Germany; Department of Neurology, University of Medicine and Pharmacy Craiova, Romania. Electronic address: aurel.popa-wagner@geriatrics-healthyageing.com.
Source: Mechanisms of ageing and development [Mech Ageing Dev] 2026 Jul 12, pp. 112231. Date of Electronic Publication: 2026 Jul 12.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 0347227 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6216 (Electronic) Linking ISSN: 00476374 NLM ISO Abbreviation: Mech Ageing Dev Subsets: MEDLINE
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  Data: Biological limits of lifespan extension: evidence for a shift from pathway leverage to system-level buffering across species.
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  Data: <searchLink fieldCode="AU" term="%22Pirscoveanu+DF%22">Pirscoveanu DF</searchLink>; Chair of Vascular Neurology and Dementia, Department of Neurology, University Hospital Essen, Essen 45147, Germany; Department of Neurology, University of Medicine and Pharmacy Craiova, Romania.<br /><searchLink fieldCode="AU" term="%22Papa+MC%22">Papa MC</searchLink>; Department of Neurology, University of Medicine and Pharmacy Craiova, Romania.<br /><searchLink fieldCode="AU" term="%22Kaltwasser+B%22">Kaltwasser B</searchLink>; Chair of Vascular Neurology and Dementia, Department of Neurology, University Hospital Essen, Essen 45147, Germany.<br /><searchLink fieldCode="AU" term="%22Hermann+DM%22">Hermann DM</searchLink>; Chair of Vascular Neurology and Dementia, Department of Neurology, University Hospital Essen, Essen 45147, Germany; Department of Neurology, University of Medicine and Pharmacy Craiova, Romania.<br /><searchLink fieldCode="AU" term="%22Brockmeier+U%22">Brockmeier U</searchLink>; Chair of Vascular Neurology and Dementia, Department of Neurology, University Hospital Essen, Essen 45147, Germany.<br /><searchLink fieldCode="AU" term="%22Cercel+A%22">Cercel A</searchLink>; Chair of Vascular Neurology and Dementia, Department of Neurology, University Hospital Essen, Essen 45147, Germany; Department of Neurology, University of Medicine and Pharmacy Craiova, Romania.<br /><searchLink fieldCode="AU" term="%22Oliver+A%22">Oliver A</searchLink>; Ravan Bio Ltd, Unit 7A, Kilburn House, Lloyd St North, Manchester, M15 6SE, UK.<br /><searchLink fieldCode="AU" term="%22Gruillari+J%22">Gruillari J</searchLink>; Ludwig Boltzmann Institute for Traumatology, Research Center in cooperation with AUVA, Vienna, Austria; Austrian Cluster for Tissue Regeneration, Vienna, Austria; Institute of Molecular Biotechnology, BOKU - University, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Ionica+MV%22">Ionica MV</searchLink>; Chair of Vascular Neurology and Dementia, Department of Neurology, University Hospital Essen, Essen 45147, Germany; Department of Neurology, University of Medicine and Pharmacy Craiova, Romania. Electronic address: mionica2@yahoo.com.<br /><searchLink fieldCode="AU" term="%22Popa-Wagner+A%22">Popa-Wagner A</searchLink>; Chair of Vascular Neurology and Dementia, Department of Neurology, University Hospital Essen, Essen 45147, Germany; Department of Neurology, University of Medicine and Pharmacy Craiova, Romania. Electronic address: aurel.popa-wagner@geriatrics-healthyageing.com.
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  Data: <searchLink fieldCode="JN" term="%220347227%22">Mechanisms of ageing and development</searchLink> [Mech Ageing Dev] 2026 Jul 12, pp. 112231. <i>Date of Electronic Publication: </i>2026 Jul 12.
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              Text: 2026 Jul 12
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