Ubiquitination of ACSL4 by Parkin Suppresses Ferroptosis and Rescues Glucocorticoid-Induced Bone Loss.

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Title: Ubiquitination of ACSL4 by Parkin Suppresses Ferroptosis and Rescues Glucocorticoid-Induced Bone Loss.
Authors: Han LJ; Key Laboratory of Orthopaedics of Zhejiang Province, Department of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.; Key Laboratory of Osteoporosis and Geriatric Bone Health of Wenzhou, Wenzhou, Zhejiang, China., Miao JS; Key Laboratory of Orthopaedics of Zhejiang Province, Department of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.; Key Laboratory of Osteoporosis and Geriatric Bone Health of Wenzhou, Wenzhou, Zhejiang, China., Shi YF; Key Laboratory of Orthopaedics of Zhejiang Province, Department of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.; Key Laboratory of Osteoporosis and Geriatric Bone Health of Wenzhou, Wenzhou, Zhejiang, China.; Department of Orthopedics, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China., Tu YT; Key Laboratory of Orthopaedics of Zhejiang Province, Department of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.; Key Laboratory of Osteoporosis and Geriatric Bone Health of Wenzhou, Wenzhou, Zhejiang, China., Lin YZ; Key Laboratory of Orthopaedics of Zhejiang Province, Department of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.; Key Laboratory of Osteoporosis and Geriatric Bone Health of Wenzhou, Wenzhou, Zhejiang, China., Chen LJ; Key Laboratory of Orthopaedics of Zhejiang Province, Department of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.; Key Laboratory of Osteoporosis and Geriatric Bone Health of Wenzhou, Wenzhou, Zhejiang, China., Lin BH; Key Laboratory of Orthopaedics of Zhejiang Province, Department of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.; Key Laboratory of Osteoporosis and Geriatric Bone Health of Wenzhou, Wenzhou, Zhejiang, China., Li HL; Key Laboratory of Orthopaedics of Zhejiang Province, Department of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.; Key Laboratory of Osteoporosis and Geriatric Bone Health of Wenzhou, Wenzhou, Zhejiang, China., Zheng XQ; Key Laboratory of Orthopaedics of Zhejiang Province, Department of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.; Key Laboratory of Osteoporosis and Geriatric Bone Health of Wenzhou, Wenzhou, Zhejiang, China., Wu HQ; Key Laboratory of Orthopaedics of Zhejiang Province, Department of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.; Key Laboratory of Osteoporosis and Geriatric Bone Health of Wenzhou, Wenzhou, Zhejiang, China., Liu HX; Key Laboratory of Orthopaedics of Zhejiang Province, Department of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.; Key Laboratory of Osteoporosis and Geriatric Bone Health of Wenzhou, Wenzhou, Zhejiang, China., Yang L; Key Laboratory of Orthopaedics of Zhejiang Province, Department of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.; Key Laboratory of Osteoporosis and Geriatric Bone Health of Wenzhou, Wenzhou, Zhejiang, China., Wu AM; Key Laboratory of Orthopaedics of Zhejiang Province, Department of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.; Key Laboratory of Osteoporosis and Geriatric Bone Health of Wenzhou, Wenzhou, Zhejiang, China., Lin Z; Key Laboratory of Orthopaedics of Zhejiang Province, Department of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.; Key Laboratory of Osteoporosis and Geriatric Bone Health of Wenzhou, Wenzhou, Zhejiang, China.; Department of Plastic and Aesthetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China., Xiao J; Key Laboratory of Orthopaedics of Zhejiang Province, Department of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.; Key Laboratory of Osteoporosis and Geriatric Bone Health of Wenzhou, Wenzhou, Zhejiang, China., Zheng G; Key Laboratory of Orthopaedics of Zhejiang Province, Department of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.; Key Laboratory of Osteoporosis and Geriatric Bone Health of Wenzhou, Wenzhou, Zhejiang, China., Jin C; Key Laboratory of Orthopaedics of Zhejiang Province, Department of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.; Key Laboratory of Osteoporosis and Geriatric Bone Health of Wenzhou, Wenzhou, Zhejiang, China.
Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2026 Jul 13, pp. e76586. Date of Electronic Publication: 2026 Jul 13.
Publication Type: Journal Article
Journal Info: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2198-3844
DOI:10.1002/advs.76586