Structural design and cytotoxic profiling of a novel 1,3,4-thiadiazole derivative targeting MCF-7 and HCT-116 cell lines: synthesis, cytotoxicity, and in silico study.

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Title: Structural design and cytotoxic profiling of a novel 1,3,4-thiadiazole derivative targeting MCF-7 and HCT-116 cell lines: synthesis, cytotoxicity, and in silico study.
Authors: Sayed M; School of Materials and Chemistry, Southwest University of Science and Technology Mianyang 621010 China.; Department of Chemistry, Faculty of Science, New Valley University El-Kharja 72511 Egypt drmostafa@scinv.au.edu.eg., Mohammed E; Department of Chemistry, Faculty of Science, New Valley University El-Kharja 72511 Egypt drmostafa@scinv.au.edu.eg., Aboubaker DH; Medicinal and Aromatic Plants Department, Pharmaceutical and Drug Industries Institute, National Research Centre Dokki Giza 12622 Egypt., El-Rashedy AA; Natural and Microbial Products Department, National Research Center (NRC) Cairo 12622 Egypt., Hassanien R; Department of Chemistry, Faculty of Science, New Valley University El-Kharja 72511 Egypt drmostafa@scinv.au.edu.eg., Tolba MS; Department of Chemistry, Faculty of Science, New Valley University El-Kharja 72511 Egypt drmostafa@scinv.au.edu.eg., Ahmed M; Department of Chemistry, Faculty of Science, New Valley University El-Kharja 72511 Egypt drmostafa@scinv.au.edu.eg.
Source: RSC advances [RSC Adv] 2026 Jul 06. Date of Electronic Publication: 2026 Jul 06.
Publication Type: Journal Article
Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101581657 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2046-2069 (Electronic) Linking ISSN: 20462069 NLM ISO Abbreviation: RSC Adv
Database: MEDLINE Ultimate
Description
ISSN:2046-2069
DOI:10.1039/d6ra03908a