Amyloid PET Quantitation and Centiloid Thresholds in the Diagnosis of Alzheimer Disease: An Individual Participant Data Meta-Analysis.

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Title: Amyloid PET Quantitation and Centiloid Thresholds in the Diagnosis of Alzheimer Disease: An Individual Participant Data Meta-Analysis.
Authors: Blazhenets G; Edward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco., Soleimani-Meigooni DN; Edward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco.; Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, California., Chiotis K; Edward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco.; Center for Alzheimer Research, Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden., Allen IE; Edward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco., Rabinovici GD; Edward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco.; Department of Radiology and Biomedical Imaging, University of California, San Francisco., La Joie R; Edward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco., Apostolova LG; Indiana University School of Medicine, Indianapolis., Asken BM; Department of Clinical and Health Psychology, 1Florida Alzheimer's Disease Research Center, University of Florida, Gainesville., Bejanin A; Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Facultad de Medicina - Universitat Autònoma de Barcelona, Barcelona, Spain.; Center of Biomedical Investigation Network for Neurodegenerative Diseases, Madrid, Spain., Benzinger TLS; Department of Radiology, Washington University in St Louis, St Louis, Missouri., Betthauser TJ; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison.; Department of Medicine, University of Wisconsin, Madison., Bluma M; Center for Alzheimer Research, Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden., Bombois S; Institute of Memory and Alzheimer's Disease, Department of Neurology, Pitié-Salpêtrière Hospital, AP-HP, Paris, France., Bourgeat P; Australian eHealth Research Centre, CSIRO, Brisbane, Australia., Bouteloup V; Université de Bordeaux, Bordeaux, France.; Pôle de Santé Publique Centre Hospitalier Universitaire de Bordeaux, Inserm, UMR 1219, Inserm, CIC 1401-EC, Bordeaux, France., Braskie MN; Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles., Brendel M; Department of Nuclear Medicine, University Hospital of Munich, Munich, Germany.; Munich Cluster for Systems Neurology, Munich, Germany.; German Center for Neurodegenerative Diseases, Munich, Germany., Brickman AM; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York., Bryant N; University of California, Irvine., Bullich S; Life Molecular Imaging GmbH, Berlin, Germany., Carrillo MC; Medical and Scientific Relations, Alzheimer's Association, Chicago, Illinois., Casaletto K; Edward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco., Cash DM; Dementia Research Centre, UCL Queen Square Institute of Neurology, London, United Kingdom., Chang CC; Department of Neurology, Cognition and Aging Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.; Department of Medicine, National Sun Yat-Sen University, Taiwan., Chang HI; Department of Neurology, Cognition and Aging Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan., Chao Y; Department of Neuroscience, University of California, Berkeley., Chêne G; Université de Bordeaux, Bordeaux, France.; Pôle de Santé Publique Centre Hospitalier Universitaire de Bordeaux, Inserm, UMR 1219, Inserm, CIC 1401-EC, Bordeaux, France., Chételat G; Normandie Universitć, UNICAEN, INSERM, UA20, Neuropresage, Caen, France., Coath W; Dementia Research Centre, UCL Queen Square Institute of Neurology, London, United Kingdom., Collij LE; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Faculty of Medicine, Lund University, Lund, Sweden.; Department of Radiology and Nuclear Medicine, Amsterdam UMC, location VUmc, Amsterdam, the Netherlands.; Amsterdam Neuroscience, Brain Imaging, Amsterdam, the Netherlands., Colmant L; Department of Neurology Cliniques Universitaires Saint-Luc, Brussel, Belgium., Corrada MM; University of California, Irvine., Craft S; Wake Forest University School of Medicine, Winston-Salem, North Carolina., Dickerson BC; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston., Dubois B; Institute of Memory and Alzheimer's Disease, Department of Neurology, Pitié-Salpêtrière Hospital, AP-HP, Paris, France., Dufouil C; Université de Bordeaux, Bordeaux, France.; Pôle de Santé Publique Centre Hospitalier Universitaire de Bordeaux, Inserm, UMR 1219, Inserm, CIC 1401-EC, Bordeaux, France., Fajardo A; Department of Psychiatry, McGill University, Montreal, Quebec, Canada., Farrar G; GE HealthCare Life Sciences, Amersham, United Kingdom., Fortea J; Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Facultad de Medicina - Universitat Autònoma de Barcelona, Barcelona, Spain.; Center of Biomedical Investigation Network for Neurodegenerative Diseases, Madrid, Spain.; Barcelona Down Medical Center, Fundació Catalana de Síndrome de Down, Barcelona, Spain., Frings L; Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Frisoni GB; Laboratory of Neuroimaging of Aging, University of Geneva, Geneva, Switzerland.; Geneva Memory Centre, Department of Rehabilitation and Geriatrics, Geneva University Hospitals, Geneva, Switzerland., Gardner RC; Joseph Sagol Neuroscience Center, Sheba Medical Center, Ramat Gan, Israel., Garibotto V; Laboratory of Neuroimaging and Innovative Molecular Tracers, Geneva University Neurocentre and Faculty of Medicine, University of Geneva, Geneva, Switzerland.; Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospitals, Geneva, Switzerland.; Centre for Biomedical Imaging, University of Geneva, Geneva, Switzerland., Gnörich JS; Department of Nuclear Medicine, University Hospital of Munich, Munich, Germany., Gordon BA; Department of Radiology, Washington University in St Louis, St Louis, Missouri., Gu Y; Samsung Medical Center, Seoul, Republic of Korea.; Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, South Korea., Guan Y; Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China., Guo T; Institute of Neurological and Psychiatric Disorders, Shenzhen Bay Laboratory, Shenzhen, China., Hanseeuw BJ; Department of Neurology Cliniques Universitaires Saint-Luc, Brussel, Belgium., Hansson O; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Faculty of Medicine, Lund University, Lund, Sweden., Harrison TM; Department of Neuroscience, University of California, Berkeley., Huang Q; Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China., Huang SH; Department of Nuclear Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan., Iaccarino L; Eli Lilly and Company, Indianapolis, Indiana., Ishii K; Kindai University Faculty of Medicine, Osakasayama, Osaka, Japan., Ishi K; Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan., Jagust WJ; Department of Neuroscience, University of California, Berkeley., Johnson SC; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison.; Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison., Kato T; National Center for Geriatrics and Gerontology, Aichi, Obu, Moriokamachi, Japan., Katsumi Y; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston., Kaye J; Layton Aging and Alzheimer's Disease Center, Oregon Health & Science University, Portland., Koeppe RA; University of Michigan, Ann Arbor., Kolinger GD; Life Molecular Imaging GmbH, Berlin, Germany.; Lantheus Switzerland GmbH, Basel, Switzerland., Kramer JH; Edward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco., Landau SM; Department of Neuroscience, University of California, Berkeley., Landeau B; Normandie Universitć, UNICAEN, INSERM, UA20, Neuropresage, Caen, France., Lao PJ; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York., Lee S; Department of Nuclear Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea., Lleó A; Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Facultad de Medicina - Universitat Autònoma de Barcelona, Barcelona, Spain.; Center of Biomedical Investigation Network for Neurodegenerative Diseases, Madrid, Spain., Lopresti BJ; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Lowe VJ; Department of Radiology, Mayo Clinic, Rochester, Minnesota., Luchsinger JA; Department of Medicine, Columbia University Irving Medical Center, New York, New York.; Department of Epidemiology, Columbia University Irving Medical Center, New York, New York., Malpetti M; Department of Clinical Neurosciences, University of Cambridge and Cambridge University Hospitals NHS Trust, Cambridge, United Kingdom.; UK Dementia Research Institute at University of Cambridge, Cambridge, United Kingdom., Mao X; Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China., March A; American College of Radiology, Philadelphia, Pennsylvania., Masters CL; Alzheimer's Research Australia, University of Western Australia, Perth, Australia., Meyer PT; Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Mezenge F; Normandie Universitć, UNICAEN, INSERM, UA20, Neuropresage, Caen, France., Mormino EC; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California., Franquesa-Mullerat M; Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomèdica Sant Pau (IIB SANT PAU), Facultad de Medicina - Universitat Autònoma de Barcelona, Barcelona, Spain., Nakamura A; National Center for Geriatrics and Gerontology, Aichi, Obu, Moriokamachi, Japan., Nordberg A; Center for Alzheimer Research, Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.; Theme Inflammation and Aging, Karolinska University Hospital, Stockholm, Sweden., O'Brien JT; Department of Psychiatry, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom., O'Bryant SE; Institute for Translational Research, University of North Texas Health Science Center, Fort Worth., Pappas I; Laboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles., Peretti DE; Laboratory of Neuroimaging and Innovative Molecular Tracers, Geneva University Neurocentre and Faculty of Medicine, University of Geneva, Geneva, Switzerland., Quenon L; Institute of Neuroscience, UCLouvain, Brussels, Belgium., Rowe CC; Department of Molecular Imaging, Austin Health, Heidelberg, Victoria, Australia.; Florey Institute of Neurosciences, University of Melbourne, Melbourne, Victoria, Australia., Rowe JB; Department of Clinical Neurosciences, University of Cambridge and Cambridge University Hospitals NHS Trust, Cambridge, United Kingdom.; Medical Research Council Cognition and Brain Sciences Unit, Cambridge, United Kingdom., Rudolph MD; Wake Forest University School of Medicine, Winston-Salem, North Carolina., Salvadó G; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Faculty of Medicine, Lund University, Lund, Sweden.; Barcelona Beta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain., Schott JM; Indiana University School of Medicine, Indianapolis.; UK Dementia Research Institute at University College London, London, United Kingdom., Schwartz DL; Layton Aging and Alzheimer's Disease Center, Oregon Health & Science University, Portland., Schwarz CG; Department of Radiology, Mayo Clinic, Rochester, Minnesota., Seo SW; Samsung Medical Center, Seoul, Republic of Korea., Shekari M; Barcelona Beta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain., Silbert LC; Layton Aging and Alzheimer's Disease Center, Oregon Health & Science University, Portland., Smith R; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Faculty of Medicine, Lund University, Lund, Sweden., Snyder HM; Medical and Scientific Relations, Alzheimer's Association, Chicago, Illinois., Sokolowski A; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California., Sperling RA; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston., Sun P; Institute of Neurological and Psychiatric Disorders, Shenzhen Bay Laboratory, Shenzhen, China., Taggett JZ; Department of Neuroscience, University of California, Berkeley., Toga AW; Theme Inflammation and Aging, Karolinska University Hospital, Stockholm, Sweden., Touroutoglou A; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston., Vaillancourt DE; Department of Applied Physiology and Kinesiology, 1Florida Alzheimer's Disease Research Center, University of Florida, Gainesville., van de Giessen E; Department of Radiology and Nuclear Medicine, Amsterdam UMC, location VUmc, Amsterdam, the Netherlands., Vijverberg J; Department of Radiology and Nuclear Medicine, Amsterdam UMC, location VUmc, Amsterdam, the Netherlands., Vemuri P; Department of Radiology, Mayo Clinic, Rochester, Minnesota., Villain N; Institute of Memory and Alzheimer's Disease, Department of Neurology, Pitié-Salpêtrière Hospital, AP-HP, Paris, France., Villemagne VL; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Villeneuve S; Department of Psychiatry, McGill University, Montreal, Quebec, Canada., Wang WE; Department of Applied Physiology and Kinesiology, 1Florida Alzheimer's Disease Research Center, University of Florida, Gainesville., Weiner M; Edward and Pearl Fein Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco., Woodworth D; University of California, Irvine., Xiao C; Laboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles., Xie F; Department of Nuclear Medicine & PET Center, Huashan Hospital, Fudan University, Shanghai, China., Yoon Y; Department of Nuclear Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea., Young CB; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California.; Department of Radiology, University of California, Davis.; Department of Neurology, University of California, Davis., Yun M; Department of Nuclear Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
Corporate Authors: Meta-Centiloid Study Group, A4, ABIDE, ADNI*, ADNI-DoD, AgeWell, AIBL, AMYPAD, BACS, BATON, BIOCARD, BLSA, BioFINDER-2, BrANCH, CPAS, DETECT-AD, GEMS, GHABS, HABS, HABS-HD, IDEAS, IMAP, INSIGHT-preAD, Insight46, K-ROAD, LEADS, MCSA, MULNIAD, MEMENTO, SCAN, PREVENT-AD, SPIN, Severanc
Source: JAMA [JAMA] 2026 Jul 13. Date of Electronic Publication: 2026 Jul 13.
Publication Type: Journal Article
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1538-3598
DOI:10.1001/jama.2026.13116