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The perineurium integrates leptin with its sympathetic outflow to protect against obesity.

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Title: The perineurium integrates leptin with its sympathetic outflow to protect against obesity.
Authors: Sarker G; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Haberman E; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Chandran A; Research and Development, Novo Nordisk Research Centre Oxford, Oxford, UK., Monfeuga T; Research and Development, Novo Nordisk Research Centre Oxford, Oxford, UK., Maroteau C; Research and Development, Novo Nordisk Research Centre Oxford, Oxford, UK., Lundh S; Department of Pathology and Imaging, Global Drug Discovery, Novo Nordisk, Måløv, Denmark., Oliveira DS; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Raimondi A; Experimental Imaging Centre, IRCCS San Raffaele Scientific Institute, Milan, Italy., Ziegler K; Institute of Pharmacology and Toxicology, Technical University Munich (TUM), Munich, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany., Gomes T; Instituto de Tecnologia Química e Biológica António Xavier, ITQB NOVA, Lisbon, Portugal., Cordeiro TN; Instituto de Tecnologia Química e Biológica António Xavier, ITQB NOVA, Lisbon, Portugal., Parekh K; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Schmid E; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Fernández-Sanmartín P; Neurobesity Group, Department of Physiology, Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, Santiago, Spain., Griebel A; Institute of Pharmacology and Toxicology, Technical University Munich (TUM), Munich, Germany., Martinez-Sanchez N; Oxford Centre for Diabetes, Endocrinology and Metabolism, Oxford, UK., Arús BA; Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.; Medizinische Fakultät and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; Department of Functional Imaging in Surgical Oncology, National Center for Tumor Diseases (NCT/UCC), Dresden, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany., Cheung SW; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Zhu Y; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Shaked M; Research and Development, Novo Nordisk Research Centre Oxford, Oxford, UK., Knowles SCL; Department of Biology, University of Oxford, Oxford, UK., Engelhardt SH; Institute of Pharmacology and Toxicology, Technical University Munich (TUM), Munich, Germany., Iannacone M; Vita-Salute San Raffaele University, Milan, Italy.; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy., Scherer PE; Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA., López M; Neurobesity Group, Department of Physiology, Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, Santiago, Spain., Toledo EM; Research and Development, Novo Nordisk Research Centre Oxford, Oxford, UK., Domingos A; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK. ana.domingos@dpag.ox.ac.uk.
Source: Nature metabolism [Nat Metab] 2026 Jul; Vol. 8 (7), pp. 1563-1582. Date of Electronic Publication: 2026 Jul 13.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab Subsets: MEDLINE
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  Data: The perineurium integrates leptin with its sympathetic outflow to protect against obesity.
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  Data: <searchLink fieldCode="AU" term="%22Sarker+G%22">Sarker G</searchLink>; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Haberman+E%22">Haberman E</searchLink>; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Chandran+A%22">Chandran A</searchLink>; Research and Development, Novo Nordisk Research Centre Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Monfeuga+T%22">Monfeuga T</searchLink>; Research and Development, Novo Nordisk Research Centre Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Maroteau+C%22">Maroteau C</searchLink>; Research and Development, Novo Nordisk Research Centre Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Lundh+S%22">Lundh S</searchLink>; Department of Pathology and Imaging, Global Drug Discovery, Novo Nordisk, Måløv, Denmark.<br /><searchLink fieldCode="AU" term="%22Oliveira+DS%22">Oliveira DS</searchLink>; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Raimondi+A%22">Raimondi A</searchLink>; Experimental Imaging Centre, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Ziegler+K%22">Ziegler K</searchLink>; Institute of Pharmacology and Toxicology, Technical University Munich (TUM), Munich, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Gomes+T%22">Gomes T</searchLink>; Instituto de Tecnologia Química e Biológica António Xavier, ITQB NOVA, Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Cordeiro+TN%22">Cordeiro TN</searchLink>; Instituto de Tecnologia Química e Biológica António Xavier, ITQB NOVA, Lisbon, Portugal.<br /><searchLink fieldCode="AU" term="%22Parekh+K%22">Parekh K</searchLink>; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Schmid+E%22">Schmid E</searchLink>; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Fernández-Sanmartín+P%22">Fernández-Sanmartín P</searchLink>; Neurobesity Group, Department of Physiology, Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, Santiago, Spain.<br /><searchLink fieldCode="AU" term="%22Griebel+A%22">Griebel A</searchLink>; Institute of Pharmacology and Toxicology, Technical University Munich (TUM), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Martinez-Sanchez+N%22">Martinez-Sanchez N</searchLink>; Oxford Centre for Diabetes, Endocrinology and Metabolism, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Arús+BA%22">Arús BA</searchLink>; Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.; Medizinische Fakultät and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; Department of Functional Imaging in Surgical Oncology, National Center for Tumor Diseases (NCT/UCC), Dresden, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Cheung+SW%22">Cheung SW</searchLink>; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Zhu+Y%22">Zhu Y</searchLink>; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Shaked+M%22">Shaked M</searchLink>; Research and Development, Novo Nordisk Research Centre Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Knowles+SCL%22">Knowles SCL</searchLink>; Department of Biology, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Engelhardt+SH%22">Engelhardt SH</searchLink>; Institute of Pharmacology and Toxicology, Technical University Munich (TUM), Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Iannacone+M%22">Iannacone M</searchLink>; Vita-Salute San Raffaele University, Milan, Italy.; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Scherer+PE%22">Scherer PE</searchLink>; Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA.<br /><searchLink fieldCode="AU" term="%22López+M%22">López M</searchLink>; Neurobesity Group, Department of Physiology, Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, Santiago, Spain.<br /><searchLink fieldCode="AU" term="%22Toledo+EM%22">Toledo EM</searchLink>; Research and Development, Novo Nordisk Research Centre Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Domingos+A%22">Domingos A</searchLink>; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK. ana.domingos@dpag.ox.ac.uk.
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