Optimized Lipid Nanoparticles with Tail-Modified Ionizable Lipids for Safer mRNA Delivery.

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Title: Optimized Lipid Nanoparticles with Tail-Modified Ionizable Lipids for Safer mRNA Delivery.
Authors: Bae SH; Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea.; BK21 Plus Department of Biotechnology, The Catholic University of Korea, Bucheon, Republic of Korea., Lee J; Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea., Ahn JH; Department of Experimental Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea., Choi H; Department of Chemistry, The Catholic University of Korea, Bucheon, Republic of Korea., Choi H; Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea.; BK21 Plus Department of Biotechnology, The Catholic University of Korea, Bucheon, Republic of Korea., Kim J; Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea.; BK21 Plus Department of Biotechnology, The Catholic University of Korea, Bucheon, Republic of Korea., Kang M; BK21 Plus Department of Biotechnology, The Catholic University of Korea, Bucheon, Republic of Korea.; Department of Biomedical-Chemical Engineering, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea.; Research Institute for Controlled Biomaterials of Regulated Cell Death, The Catholic University of Korea, Bucheon, Republic of Korea., Oh HR; Department of Nuclear Medicine, Cancer Imaging Center, Seoul National University Hospital, Seoul, Republic of Korea.; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea., Park SH; College of Veterinary Medicine, Chungbuk National University, Cheongju-si, Chungcheongbuk-do, Republic of Korea., Oh EY; College of Veterinary Medicine, Chungbuk National University, Cheongju-si, Chungcheongbuk-do, Republic of Korea., Jeon S; Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea.; BK21 Plus Department of Biotechnology, The Catholic University of Korea, Bucheon, Republic of Korea., Lee Y; Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea.; BK21 Plus Department of Biotechnology, The Catholic University of Korea, Bucheon, Republic of Korea., Lee YS; Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea.; BK21 Plus Department of Biotechnology, The Catholic University of Korea, Bucheon, Republic of Korea., Lee NY; Department of Experimental Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.; Department of Veterinary Pathology and Research Institute of Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea., Bae HJ; Department of Experimental Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.; Graduate School of Translational Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea., Kwak J; Department of Experimental Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea., Kim J; Department of Experimental Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea., Lee N; Department of Chemistry, The Catholic University of Korea, Bucheon, Republic of Korea., Kang B; Department of Chemistry, The Catholic University of Korea, Bucheon, Republic of Korea., Kim JH; BK21 Plus Department of Biotechnology, The Catholic University of Korea, Bucheon, Republic of Korea.; Department of Biomedical-Chemical Engineering, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea.; Research Institute for Controlled Biomaterials of Regulated Cell Death, The Catholic University of Korea, Bucheon, Republic of Korea., Song E; BK21 Plus Department of Biotechnology, The Catholic University of Korea, Bucheon, Republic of Korea.; Department of Biomedical-Chemical Engineering, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea.; Research Institute for Controlled Biomaterials of Regulated Cell Death, The Catholic University of Korea, Bucheon, Republic of Korea., Song D; Department of Virology, College of Veterinary Medicine and Research Institute For Veterinary Science, Seoul National University, Seoul, Republic of Korea., Yoon H; Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea.; BK21 Plus Department of Biotechnology, The Catholic University of Korea, Bucheon, Republic of Korea., Lee SM; College of Veterinary Medicine, Chungbuk National University, Cheongju-si, Chungcheongbuk-do, Republic of Korea., Youn H; Department of Nuclear Medicine, Cancer Imaging Center, Seoul National University Hospital, Seoul, Republic of Korea.; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea., Lee K; Department of Chemistry, The Catholic University of Korea, Bucheon, Republic of Korea., Kang BC; Department of Experimental Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.; Graduate School of Translational Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea., Nam JH; Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea.; BK21 Plus Department of Biotechnology, The Catholic University of Korea, Bucheon, Republic of Korea.; National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju-si, Chungcheongbuk-do, Republic of Korea.
Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2026 Jul 14, pp. e76539. Date of Electronic Publication: 2026 Jul 14.
Publication Type: Journal Article
Journal Info: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2198-3844
DOI:10.1002/advs.76539