Optimized Lipid Nanoparticles with Tail-Modified Ionizable Lipids for Safer mRNA Delivery.
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| Title: | Optimized Lipid Nanoparticles with Tail-Modified Ionizable Lipids for Safer mRNA Delivery. |
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| Authors: | Bae SH; Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea.; BK21 Plus Department of Biotechnology, The Catholic University of Korea, Bucheon, Republic of Korea., Lee J; Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea., Ahn JH; Department of Experimental Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea., Choi H; Department of Chemistry, The Catholic University of Korea, Bucheon, Republic of Korea., Choi H; Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea.; BK21 Plus Department of Biotechnology, The Catholic University of Korea, Bucheon, Republic of Korea., Kim J; Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea.; BK21 Plus Department of Biotechnology, The Catholic University of Korea, Bucheon, Republic of Korea., Kang M; BK21 Plus Department of Biotechnology, The Catholic University of Korea, Bucheon, Republic of Korea.; Department of Biomedical-Chemical Engineering, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea.; Research Institute for Controlled Biomaterials of Regulated Cell Death, The Catholic University of Korea, Bucheon, Republic of Korea., Oh HR; Department of Nuclear Medicine, Cancer Imaging Center, Seoul National University Hospital, Seoul, Republic of Korea.; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea., Park SH; College of Veterinary Medicine, Chungbuk National University, Cheongju-si, Chungcheongbuk-do, Republic of Korea., Oh EY; College of Veterinary Medicine, Chungbuk National University, Cheongju-si, Chungcheongbuk-do, Republic of Korea., Jeon S; Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea.; BK21 Plus Department of Biotechnology, The Catholic University of Korea, Bucheon, Republic of Korea., Lee Y; Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea.; BK21 Plus Department of Biotechnology, The Catholic University of Korea, Bucheon, Republic of Korea., Lee YS; Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea.; BK21 Plus Department of Biotechnology, The Catholic University of Korea, Bucheon, Republic of Korea., Lee NY; Department of Experimental Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.; Department of Veterinary Pathology and Research Institute of Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea., Bae HJ; Department of Experimental Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.; Graduate School of Translational Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea., Kwak J; Department of Experimental Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea., Kim J; Department of Experimental Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea., Lee N; Department of Chemistry, The Catholic University of Korea, Bucheon, Republic of Korea., Kang B; Department of Chemistry, The Catholic University of Korea, Bucheon, Republic of Korea., Kim JH; BK21 Plus Department of Biotechnology, The Catholic University of Korea, Bucheon, Republic of Korea.; Department of Biomedical-Chemical Engineering, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea.; Research Institute for Controlled Biomaterials of Regulated Cell Death, The Catholic University of Korea, Bucheon, Republic of Korea., Song E; BK21 Plus Department of Biotechnology, The Catholic University of Korea, Bucheon, Republic of Korea.; Department of Biomedical-Chemical Engineering, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea.; Research Institute for Controlled Biomaterials of Regulated Cell Death, The Catholic University of Korea, Bucheon, Republic of Korea., Song D; Department of Virology, College of Veterinary Medicine and Research Institute For Veterinary Science, Seoul National University, Seoul, Republic of Korea., Yoon H; Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea.; BK21 Plus Department of Biotechnology, The Catholic University of Korea, Bucheon, Republic of Korea., Lee SM; College of Veterinary Medicine, Chungbuk National University, Cheongju-si, Chungcheongbuk-do, Republic of Korea., Youn H; Department of Nuclear Medicine, Cancer Imaging Center, Seoul National University Hospital, Seoul, Republic of Korea.; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea., Lee K; Department of Chemistry, The Catholic University of Korea, Bucheon, Republic of Korea., Kang BC; Department of Experimental Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.; Graduate School of Translational Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea., Nam JH; Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea.; BK21 Plus Department of Biotechnology, The Catholic University of Korea, Bucheon, Republic of Korea.; National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju-si, Chungcheongbuk-do, Republic of Korea. |
| Source: | Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2026 Jul 14, pp. e76539. Date of Electronic Publication: 2026 Jul 14. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42446186 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Optimized Lipid Nanoparticles with Tail-Modified Ionizable Lipids for Safer mRNA Delivery. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Bae+SH%22">Bae SH</searchLink>; Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea.; BK21 Plus Department of Biotechnology, The Catholic University of Korea, Bucheon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+J%22">Lee J</searchLink>; Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Ahn+JH%22">Ahn JH</searchLink>; Department of Experimental Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Choi+H%22">Choi H</searchLink>; Department of Chemistry, The Catholic University of Korea, Bucheon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Choi+H%22">Choi H</searchLink>; Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea.; BK21 Plus Department of Biotechnology, The Catholic University of Korea, Bucheon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+J%22">Kim J</searchLink>; Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea.; BK21 Plus Department of Biotechnology, The Catholic University of Korea, Bucheon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kang+M%22">Kang M</searchLink>; BK21 Plus Department of Biotechnology, The Catholic University of Korea, Bucheon, Republic of Korea.; Department of Biomedical-Chemical Engineering, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea.; Research Institute for Controlled Biomaterials of Regulated Cell Death, The Catholic University of Korea, Bucheon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Oh+HR%22">Oh HR</searchLink>; Department of Nuclear Medicine, Cancer Imaging Center, Seoul National University Hospital, Seoul, Republic of Korea.; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Park+SH%22">Park SH</searchLink>; College of Veterinary Medicine, Chungbuk National University, Cheongju-si, Chungcheongbuk-do, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Oh+EY%22">Oh EY</searchLink>; College of Veterinary Medicine, Chungbuk National University, Cheongju-si, Chungcheongbuk-do, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Jeon+S%22">Jeon S</searchLink>; Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea.; BK21 Plus Department of Biotechnology, The Catholic University of Korea, Bucheon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+Y%22">Lee Y</searchLink>; Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea.; BK21 Plus Department of Biotechnology, The Catholic University of Korea, Bucheon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+YS%22">Lee YS</searchLink>; Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea.; BK21 Plus Department of Biotechnology, The Catholic University of Korea, Bucheon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+NY%22">Lee NY</searchLink>; Department of Experimental Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.; Department of Veterinary Pathology and Research Institute of Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Bae+HJ%22">Bae HJ</searchLink>; Department of Experimental Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.; Graduate School of Translational Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kwak+J%22">Kwak J</searchLink>; Department of Experimental Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+J%22">Kim J</searchLink>; Department of Experimental Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+N%22">Lee N</searchLink>; Department of Chemistry, The Catholic University of Korea, Bucheon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kang+B%22">Kang B</searchLink>; Department of Chemistry, The Catholic University of Korea, Bucheon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+JH%22">Kim JH</searchLink>; BK21 Plus Department of Biotechnology, The Catholic University of Korea, Bucheon, Republic of Korea.; Department of Biomedical-Chemical Engineering, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea.; Research Institute for Controlled Biomaterials of Regulated Cell Death, The Catholic University of Korea, Bucheon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Song+E%22">Song E</searchLink>; BK21 Plus Department of Biotechnology, The Catholic University of Korea, Bucheon, Republic of Korea.; Department of Biomedical-Chemical Engineering, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea.; Research Institute for Controlled Biomaterials of Regulated Cell Death, The Catholic University of Korea, Bucheon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Song+D%22">Song D</searchLink>; Department of Virology, College of Veterinary Medicine and Research Institute For Veterinary Science, Seoul National University, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Yoon+H%22">Yoon H</searchLink>; Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea.; BK21 Plus Department of Biotechnology, The Catholic University of Korea, Bucheon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+SM%22">Lee SM</searchLink>; College of Veterinary Medicine, Chungbuk National University, Cheongju-si, Chungcheongbuk-do, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Youn+H%22">Youn H</searchLink>; Department of Nuclear Medicine, Cancer Imaging Center, Seoul National University Hospital, Seoul, Republic of Korea.; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+K%22">Lee K</searchLink>; Department of Chemistry, The Catholic University of Korea, Bucheon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kang+BC%22">Kang BC</searchLink>; Department of Experimental Animal Research, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.; Graduate School of Translational Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Nam+JH%22">Nam JH</searchLink>; Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon, Gyeonggi-do, Republic of Korea.; BK21 Plus Department of Biotechnology, The Catholic University of Korea, Bucheon, Republic of Korea.; National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju-si, Chungcheongbuk-do, Republic of Korea. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101664569%22">Advanced science (Weinheim, Baden-Wurttemberg, Germany)</searchLink> [Adv Sci (Weinh)] 2026 Jul 14, pp. e76539. <i>Date of Electronic Publication: </i>2026 Jul 14. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22WILEY-VCH%22">WILEY-VCH </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>101664569 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2198-3844 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2221983844%22">21983844 </searchLink><i>NLM ISO Abbreviation: </i>Adv Sci (Weinh) <i>Subsets: </i>MEDLINE |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/advs.76539 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: e76539 Titles: – TitleFull: Optimized Lipid Nanoparticles with Tail-Modified Ionizable Lipids for Safer mRNA Delivery. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Bae SH – PersonEntity: Name: NameFull: Lee J – PersonEntity: Name: NameFull: Ahn JH – PersonEntity: Name: NameFull: Choi H – PersonEntity: Name: NameFull: Choi H – PersonEntity: Name: NameFull: Kim J – PersonEntity: Name: NameFull: Kang M – PersonEntity: Name: NameFull: Oh HR – PersonEntity: Name: NameFull: Park SH – PersonEntity: Name: NameFull: Oh EY – PersonEntity: Name: NameFull: Jeon S – PersonEntity: Name: NameFull: Lee Y – PersonEntity: Name: NameFull: Lee YS – PersonEntity: Name: NameFull: Lee NY – PersonEntity: Name: NameFull: Bae HJ – PersonEntity: Name: NameFull: Kwak J – PersonEntity: Name: NameFull: Kim J – PersonEntity: Name: NameFull: Lee N – PersonEntity: Name: NameFull: Kang B – PersonEntity: Name: NameFull: Kim JH – PersonEntity: Name: NameFull: Song E – PersonEntity: Name: NameFull: Song D – PersonEntity: Name: NameFull: Yoon H – PersonEntity: Name: NameFull: Lee SM – PersonEntity: Name: NameFull: Youn H – PersonEntity: Name: NameFull: Lee K – PersonEntity: Name: NameFull: Kang BC – PersonEntity: Name: NameFull: Nam JH IsPartOfRelationships: – BibEntity: Dates: – D: 14 M: 07 Text: 2026 Jul 14 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2198-3844 Titles: – TitleFull: Advanced science (Weinheim, Baden-Wurttemberg, Germany) Type: main |
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