From empirical screening to lipid trolling: the evolution of extrahelical allosteric modulators of A1 and A3 adenosine receptors.

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Title: From empirical screening to lipid trolling: the evolution of extrahelical allosteric modulators of A1 and A3 adenosine receptors.
Authors: Pavan M; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA., Kurma SH; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA., Oliva P; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA., Broughton DP; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA., Gao ZG; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA., Auchampach JA; Department of Pharmacology & Toxicology and the Cardiovascular Center, Medical College of Wisconsin, Milwaukee, WI, USA., Jacobson KA; Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. kennethj@niddk.nih.gov.
Source: Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents [Med Chem Res] 2026 Mar 16. Date of Electronic Publication: 2026 Mar 16.
Publication Type: Journal Article; Review
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 9211347 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8120 (Electronic) Linking ISSN: 10542523 NLM ISO Abbreviation: Med Chem Res Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1554-8120
DOI:10.1007/s00044-026-03534-5