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MRS2339, a cardiac P2X4 receptor nucleotide activator, improves systolic function in heart failure.

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Title: MRS2339, a cardiac P2X4 receptor nucleotide activator, improves systolic function in heart failure.
Authors: Yang R; Pat and Jim Calhoun Cardiology Center, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT, MC-3946, 06030, USA., Cronin C; Pat and Jim Calhoun Cardiology Center, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT, MC-3946, 06030, USA., Qanud K; New York Medical College, Valhalla, 10595, NY, USA., Kumar TS; National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, 20892, MD, USA., Hintze T; New York Medical College, Valhalla, 10595, NY, USA., Recchia FA; Institute of Clinical Physiology of the National Research Council, Pisa, Italy.; Department of Medicine, University of Chicago, Chicago, IL, USA., Stojilkovic SS; National Institute of Child Health and Human Development, National Institutes of Health, Coquimbo, Chile., Coddou C; Departamento de Ciencias Biomédicas, Facultad de Medicina, Universidad Católica del Norte, Coquimbo, Chile., Jacobson KA; National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, 20892, MD, USA., Liang BT; Pat and Jim Calhoun Cardiology Center, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT, MC-3946, 06030, USA. bliang@uchc.edu.
Source: Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents [Med Chem Res] 2026 May 21. Date of Electronic Publication: 2026 May 21.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 9211347 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8120 (Electronic) Linking ISSN: 10542523 NLM ISO Abbreviation: Med Chem Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Yang+R%22">Yang R</searchLink>; Pat and Jim Calhoun Cardiology Center, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT, MC-3946, 06030, USA.<br /><searchLink fieldCode="AU" term="%22Cronin+C%22">Cronin C</searchLink>; Pat and Jim Calhoun Cardiology Center, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT, MC-3946, 06030, USA.<br /><searchLink fieldCode="AU" term="%22Qanud+K%22">Qanud K</searchLink>; New York Medical College, Valhalla, 10595, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kumar+TS%22">Kumar TS</searchLink>; National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, 20892, MD, USA.<br /><searchLink fieldCode="AU" term="%22Hintze+T%22">Hintze T</searchLink>; New York Medical College, Valhalla, 10595, NY, USA.<br /><searchLink fieldCode="AU" term="%22Recchia+FA%22">Recchia FA</searchLink>; Institute of Clinical Physiology of the National Research Council, Pisa, Italy.; Department of Medicine, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Stojilkovic+SS%22">Stojilkovic SS</searchLink>; National Institute of Child Health and Human Development, National Institutes of Health, Coquimbo, Chile.<br /><searchLink fieldCode="AU" term="%22Coddou+C%22">Coddou C</searchLink>; Departamento de Ciencias Biomédicas, Facultad de Medicina, Universidad Católica del Norte, Coquimbo, Chile.<br /><searchLink fieldCode="AU" term="%22Jacobson+KA%22">Jacobson KA</searchLink>; National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, 20892, MD, USA.<br /><searchLink fieldCode="AU" term="%22Liang+BT%22">Liang BT</searchLink>; Pat and Jim Calhoun Cardiology Center, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT, MC-3946, 06030, USA. bliang@uchc.edu.
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        Value: 10.1007/s00044-026-03575-w
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              Text: 2026 May 21
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              Y: 2026
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