Cell line identity rather than medium composition determines transcriptomic profiles of HepaRG and HuH7 cells cultured in chemically defined or serum-based media: comparison with primary human hepatocytes.

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Title: Cell line identity rather than medium composition determines transcriptomic profiles of HepaRG and HuH7 cells cultured in chemically defined or serum-based media: comparison with primary human hepatocytes.
Authors: Ali ASM; Chair of Applied Biochemistry, Institute of Biotechnology, Technische Universität Berlin, 10623, Berlin, Germany., Sprenger H; Department Chemical and Product Safety, German Federal Institute for Risk Assessment (BfR), 10589, Berlin, Germany., Braeuning A; Department Chemical and Product Safety, German Federal Institute for Risk Assessment (BfR), 10589, Berlin, Germany., Kurreck J; Chair of Applied Biochemistry, Institute of Biotechnology, Technische Universität Berlin, 10623, Berlin, Germany. jens.kurreck@tu-berlin.de.
Source: Archives of toxicology [Arch Toxicol] 2026 Jul 14. Date of Electronic Publication: 2026 Jul 14.
Publication Type: Journal Article
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Cell line identity rather than medium composition determines transcriptomic profiles of HepaRG and HuH7 cells cultured in chemically defined or serum-based media: comparison with primary human hepatocytes.
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  Data: <searchLink fieldCode="AU" term="%22Ali+ASM%22">Ali ASM</searchLink>; Chair of Applied Biochemistry, Institute of Biotechnology, Technische Universität Berlin, 10623, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Sprenger+H%22">Sprenger H</searchLink>; Department Chemical and Product Safety, German Federal Institute for Risk Assessment (BfR), 10589, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Braeuning+A%22">Braeuning A</searchLink>; Department Chemical and Product Safety, German Federal Institute for Risk Assessment (BfR), 10589, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Kurreck+J%22">Kurreck J</searchLink>; Chair of Applied Biochemistry, Institute of Biotechnology, Technische Universität Berlin, 10623, Berlin, Germany. jens.kurreck@tu-berlin.de.
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        Value: 10.1007/s00204-026-04502-z
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      – Code: eng
        Text: English
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      – TitleFull: Cell line identity rather than medium composition determines transcriptomic profiles of HepaRG and HuH7 cells cultured in chemically defined or serum-based media: comparison with primary human hepatocytes.
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            – D: 14
              M: 07
              Text: 2026 Jul 14
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              Y: 2026
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