Chalcones as multitarget modulators in non-small cell lung cancer: mechanistic insights and therapeutic perspectives.

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Title: Chalcones as multitarget modulators in non-small cell lung cancer: mechanistic insights and therapeutic perspectives.
Authors: Cruz EMS; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil. ellen.souzacruz@uel.br., Concato-Lopes VM; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil., Detoni MB; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil., Gonçalves-Lens MD; Laboratory of Biotransformation and Phytochemical, Department of Chemistry, Center of Exact Sciences, State University of Londrina, Londrina, PR, Brazil., de Souza MC, Inoue FSR; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil., Nunes AP; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil., da Silva Siqueira E; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil., Rodrigues ACJ; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil., Dos Santos-Destro YM; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil., Santos NC; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil., de Sousa Silva JM; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil., da Silva ÉI; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil., Providello MV; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil., Lazarin-Bidóia D; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil., Seiva FRF; Laboratory of Biochemistry and Experimental Morphology, Department of Chemistry and Biochemistry, São Paulo State University Júlio de Mesquita Filho, Institute of Biosciences of Botucatu, São Paulo, Brazil., Pavanelli WR; Laboratory of Immunoparasitology of Neglected Diseases and Cancer, Department of Immunology, Parasitology and General Pathology, Center of Biological Sciences, State University of Londrina - UEL, Rodovia Celso Garcia Cid Campus, Post Box 10.011, Londrina, PR, 86057-970, Brazil. wanderpavanelli@uel.br.
Source: Archives of toxicology [Arch Toxicol] 2026 Jul 14. Date of Electronic Publication: 2026 Jul 14.
Publication Type: Journal Article; Review
Journal Info: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1432-0738
DOI:10.1007/s00204-026-04501-0