Tryptophan degradation by intestinal Bacteroides induces anti-tumor immunity and limits melanoma growth.

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Title: Tryptophan degradation by intestinal Bacteroides induces anti-tumor immunity and limits melanoma growth.
Authors: Olea XD; Translational Research Institute, Elinor and Rendall Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Biomedical Sciences, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA., Beede K; Department of Food Science and Technology, Nebraska Food for Health Center, University of Nebraska-Lincoln, Lincoln, NE 68588, USA., Pereira G; Department of Microbiology & Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Scott D; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA., Petucci C; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Martens E; Department of Microbiology & Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA., Rodionov D; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA., Shah A; Translational Research Institute, Elinor and Rendall Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA., Martinez MP; Division of Molecular Oncology & Immunology, the Netherlands Cancer Institute, Amsterdam 1066 CX, the Netherlands., Kim H; Translational Research Institute, Elinor and Rendall Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA., Sharma AK; Human Microbiome Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA., Martin A; Human Microbiome Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA., Zhang T; Division of Cancer Epidemiology & Genetics, National Cancer Institute, Rockville, MD 20892, USA., Faries MB; The Angeles Clinic and Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90025, USA., Hamid O; The Angeles Clinic and Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90025, USA., Devkota S; Department of Biomedical Sciences, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA; Human Microbiome Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA., Osterman A; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA., Knott S; Translational Research Institute, Elinor and Rendall Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA., Voest EE; Division of Molecular Oncology & Immunology, the Netherlands Cancer Institute, Amsterdam 1066 CX, the Netherlands., Ajami NJ; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Wargo J; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Ramer-Tait AE; Department of Food Science and Technology, Nebraska Food for Health Center, University of Nebraska-Lincoln, Lincoln, NE 68588, USA. Electronic address: aramer-tai2@unl.edu., Ronai ZA; Translational Research Institute, Elinor and Rendall Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA; Department of Biomedical Sciences, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA. Electronic address: zeev.ronai@csmc.edu.
Source: Cell reports. Medicine [Cell Rep Med] 2026 Jul 14, pp. 102921. Date of Electronic Publication: 2026 Jul 14.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2666-3791
DOI:10.1016/j.xcrm.2026.102921