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Harmonized metagenomic signatures of the gut microbiome reveal robust species, functions, and strain links to inflammatory bowel disease.

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Title: Harmonized metagenomic signatures of the gut microbiome reveal robust species, functions, and strain links to inflammatory bowel disease.
Authors: Thompson KN; Harvard Chan Microbiome in Public Health Center, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Ma S; Department of Biostatistics, Vanderbilt University Medical Center, Vanderbilt, TN, USA., Bhosle A; Harvard Chan Microbiome in Public Health Center, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Nickols WA; Harvard Chan Microbiome in Public Health Center, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Shen J; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Ghazi AR; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Dang NH; Harvard Chan Microbiome in Public Health Center, Boston, MA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Zhang Y; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Nzabarushimana E; Harvard Chan Microbiome in Public Health Center, Boston, MA, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Kim H; Harvard Chan Microbiome in Public Health Center, Boston, MA, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Xavier RJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Chan AT; Harvard Chan Microbiome in Public Health Center, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Franzosa EA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Huttenhower C; Harvard Chan Microbiome in Public Health Center, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address: chuttenh@hsph.harvard.edu., Nguyen LH; Harvard Chan Microbiome in Public Health Center, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: lnguyen24@mgh.harvard.edu.
Source: Gastroenterology [Gastroenterology] 2026 Jul 14. Date of Electronic Publication: 2026 Jul 14.
Publication Type: Journal Article
Journal Info: Publisher: W.B. Saunders Country of Publication: United States NLM ID: 0374630 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-0012 (Electronic) Linking ISSN: 00165085 NLM ISO Abbreviation: Gastroenterology Subsets: MEDLINE
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  Data: Harmonized metagenomic signatures of the gut microbiome reveal robust species, functions, and strain links to inflammatory bowel disease.
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  Data: <searchLink fieldCode="AU" term="%22Thompson+KN%22">Thompson KN</searchLink>; Harvard Chan Microbiome in Public Health Center, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ma+S%22">Ma S</searchLink>; Department of Biostatistics, Vanderbilt University Medical Center, Vanderbilt, TN, USA.<br /><searchLink fieldCode="AU" term="%22Bhosle+A%22">Bhosle A</searchLink>; Harvard Chan Microbiome in Public Health Center, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Nickols+WA%22">Nickols WA</searchLink>; Harvard Chan Microbiome in Public Health Center, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Shen+J%22">Shen J</searchLink>; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ghazi+AR%22">Ghazi AR</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Dang+NH%22">Dang NH</searchLink>; Harvard Chan Microbiome in Public Health Center, Boston, MA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Nzabarushimana+E%22">Nzabarushimana E</searchLink>; Harvard Chan Microbiome in Public Health Center, Boston, MA, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kim+H%22">Kim H</searchLink>; Harvard Chan Microbiome in Public Health Center, Boston, MA, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Xavier+RJ%22">Xavier RJ</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Chan+AT%22">Chan AT</searchLink>; Harvard Chan Microbiome in Public Health Center, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Franzosa+EA%22">Franzosa EA</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Huttenhower+C%22">Huttenhower C</searchLink>; Harvard Chan Microbiome in Public Health Center, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address: chuttenh@hsph.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Nguyen+LH%22">Nguyen LH</searchLink>; Harvard Chan Microbiome in Public Health Center, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: lnguyen24@mgh.harvard.edu.
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        Value: 10.1053/j.gastro.2026.06.023
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