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Integrative multi-omics reveals MHC class II-mediated neuroinflammation and systemic metabolic dysregulation as transdiagnostic drivers in major brain disorders.

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Title: Integrative multi-omics reveals MHC class II-mediated neuroinflammation and systemic metabolic dysregulation as transdiagnostic drivers in major brain disorders.
Authors: Xu X; School of Life Sciences, Anhui Medical University, Hefei, Anhui, 230032, China. xuxuan@ahmu.edu.cn., Fan SS; School of Basic Medical Sciences, Medical School, Hubei Minzu University, Hubei, Enshi, 445000, China., Wu H; School of Life Sciences, Anhui Medical University, Hefei, Anhui, 230032, China., Du Y; School of Health Management, Anhui Medical University, Hefei, Anhui, 230032, China., Bo Y; School of Biomedical Engineering, Anhui Medical University, Hefei, Anhui, 230032, China., He J; College of Informatics, Huazhong Agricultural University, Hubei, Wuhan, 430070, China., He Y; College of Informatics, Huazhong Agricultural University, Hubei, Wuhan, 430070, China., Cheng N; School of Biomedical Engineering, Anhui Medical University, Hefei, Anhui, 230032, China. chengna@ahmu.edu.cn., Meng XY; School of Basic Medical Sciences, Medical School, Hubei Minzu University, Hubei, Enshi, 445000, China. mengxy_whu@163.com.
Source: Translational psychiatry [Transl Psychiatry] 2026 Jul 14. Date of Electronic Publication: 2026 Jul 14.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2158-3188
DOI:10.1038/s41398-026-04280-3