Multiomic profiling of responses to clinical and novel bisphosphonates reveals extraskeletal effects on ageing related signatures.
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| Title: | Multiomic profiling of responses to clinical and novel bisphosphonates reveals extraskeletal effects on ageing related signatures. |
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| Authors: | Lu J; Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Rao SR; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Knowles H; Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Zhan H; Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Gamez B; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Qin M; Department of Biochemistry, University of Oxford, Oxford, UK., Platt E; Medicines Discovery Catapult, Cheshire, UK., Frost LR; Medicines Discovery Catapult, Cheshire, UK., Allen TJ; Medicines Discovery Catapult, Cheshire, UK., Marshall G; Medicines Discovery Catapult, Cheshire, UK., Huber KVM; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Bauer LG; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Vendrell I; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., O'Brien DP; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Kessler B; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Horne A; Faculty of Medical and Health Sciences, University of Auckland, Auckland, NZ, New Zealand., Reid IR; Faculty of Medical and Health Sciences, University of Auckland, Auckland, NZ, New Zealand., Bountra C; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Kirkland JL; Center for Advanced Gerotherapeutics, Cedars-Sinai Health Sciences University, Los Angeles, USA., Khosla S; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Ebetino FH; BioVinc LLC, Pasadena, CA, US.; Department of Chemistry, University of Rochester, Rochester, NY, USA., Roldan E; Qualix DoT, Barcelona, Spain., Russell RGG; Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.; Mellanby Centre for Bone Research, Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield Medical School, Sheffield, UK., Edwards JR; Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. James.Edwards@ndorms.ox.ac.uk. |
| Source: | Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 Jul 15; Vol. 11 (1). Date of Electronic Publication: 2026 Jul 15. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2059-3635 |
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| DOI: | 10.1038/s41392-026-02799-x |
