Single-cell transcriptome reveals keratinocyte subclusters contributing to altered differentiation and inflammatory responses in atopic dermatitis.

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Title: Single-cell transcriptome reveals keratinocyte subclusters contributing to altered differentiation and inflammatory responses in atopic dermatitis.
Authors: Qin T; Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA., Bogle R; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Jiang R; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Sarkar MK; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Cai Y; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Gharaee-Kermani M; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Fox J; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Xing X; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Marella S; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Nakamura M; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA., Maverakis E; PHYSIOSEQ, Sacramento, CA, USA.; Department of Dermatology, University of California, Davis, Sacramento, CA, USA., Le ST; PHYSIOSEQ, Sacramento, CA, USA., Merleev AA; PHYSIOSEQ, Sacramento, CA, USA., Marusina AI; PHYSIOSEQ, Sacramento, CA, USA., Simpson CL; Department of Dermatology, University of Washington, Seattle, WA, USA., Parihar A; Department of Dermatology, University of Washington, Seattle, WA, USA., Hill C; Johnson & Johnson Innovative Medicine, Research & Development, Spring House, PA, USA., Li H; Johnson & Johnson Innovative Medicine, Research & Development, Spring House, PA, USA., Kahlenberg JM; Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, USA., Waterworth DM; Johnson & Johnson Innovative Medicine, Research & Development, Spring House, PA, USA., Sabins N; Johnson & Johnson Innovative Medicine, Research & Development, Spring House, PA, USA., Miller LS; Johnson & Johnson Innovative Medicine, Research & Development, Spring House, PA, USA., Freeman TC; Johnson & Johnson Innovative Medicine, Research & Development, Spring House, PA, USA., Leung MW; Johnson & Johnson Innovative Medicine, Research & Development, Spring House, PA, USA., Polak ME; Johnson & Johnson Innovative Medicine, Research & Development, Spring House, PA, USA., Tsoi LC; Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA. alextsoi@med.umich.edu.; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA. alextsoi@med.umich.edu.; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA. alextsoi@med.umich.edu.; Mary H. Weiser Food Allergy Center, University of Michigan Medical School, Ann Arbor, MI, USA. alextsoi@med.umich.edu., Billi AC; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA. acbilli@med.umich.edu., Gudjonsson JE; Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA. johanng@med.umich.edu.; Mary H. Weiser Food Allergy Center, University of Michigan Medical School, Ann Arbor, MI, USA. johanng@med.umich.edu.
Source: Nature communications [Nat Commun] 2026 Jul 14. Date of Electronic Publication: 2026 Jul 14.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-026-75407-9