Distinct molecular subgroups in pediatric and young-onset meningiomas require age-adapted risk stratification.
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| Title: | Distinct molecular subgroups in pediatric and young-onset meningiomas require age-adapted risk stratification. |
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| Authors: | Berghaus N; Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Tauziède-Espariat A; Department of Neuropathology, GHU Paris, Psychiatry and Neurosciences, Sainte-Anne Hospital, Paris, France.; Université Paris Cité, Institute of Psychiatry and Neuroscience of Paris (IPNP), Paris, France., Hielscher T; Department of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Savran D; Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Schrimpf D; Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Göbel K; Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany., Stutheit-Zhao E; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Friedrich L; Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Keller F; Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Aras FK; Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Nozzoli F; Section of Anatomic Pathology, Department of Health Sciences, University of Florence, Florence, Italy.; Histopathology and Molecular Diagnostics, Careggi University Hospital, Florence, Italy., Sturm D; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Division of Pediatric Glioma Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, University Hospital Heidelberg, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany., White CL; Genetics and Molecular Pathology Laboratory, Hudson Institute of Medical Research, Clayton, VIC, Australia.; Department of Molecular and Translational Science, Monash University, Melbourne, VIC, Australia.; Victorian Clinical Genetics Services, Parkville, VIC, Australia., Schmid S; Department of Neuropathology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany., Mawrin C; Department of Neuropathology, Otto-von-Guericke-University, Magdeburg, Germany., Neumann JE; Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Center for Molecular Neurobiology Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Acker T; Institute of Neuropathology, Justus-Liebig University Giessen, Giessen, Germany., Beschorner R; Center for Neuro-Oncology, Comprehensive Cancer Center Tübingen-Stuttgart, University Hospital Tübingen, Eberhard-Karls-University Tübingen, Tübingen, Germany.; Department of Neuropathology, University of Tübingen, Eberhard-Karls-University Tübingen, Tübingen, Germany., Hartmann C; Department of Neuropathology, Institute of Pathology, Hannover Medical School (MHH), Hannover, Germany., Saribiyik I; Department of Pathology, Gazi University, Ankara, Turkey., Inan A; Department of Pathology, Acibadem Universitesi Tip Fakultesi, Istanbul, Turkey., Erşen-Danyeli A; Department of Pathology, Acibadem Universitesi Tip Fakultesi, Istanbul, Turkey., Kranendonk MEG; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Maas SLN; Department of Pathology, Brain Tumor Center, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands., Bos EM; Department of Neurosurgery, Brain Tumor Center, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands., Aronica E; Department of (Neuro) Pathology, Amsterdam Neuroscience, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands., Peerdeman SM; Department of Neurosurgery, Amsterdam University Medical Center, Amsterdam UMC Location VU University, Amsterdam, The Netherlands., Thuijs NB; Department of Pathology, Amsterdam UMC Location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Cancer Center Amsterdam, Imaging and Biomarkers, Amsterdam, The Netherlands., Mühlebner A; Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands., Kusters B; Department of Pathology, Radboudumc, Nijmegen, The Netherlands., den Dunnen WFA; Department of Pathology and Medical Biology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands., Lavarino CE; Laboratory of Molecular Oncology, Pediatric Cancer Center Barcelona, Hospital Sant Joan de Déu, Barcelona, Spain., Puget S; Department of Neurosurgery, CHU Martinique, Fort-de-France, France., Chiang J; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA., Dahiya S; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA., Pekmezci M; Department of Pathology, University of California San Francisco (UCSF), San Francisco, CA, USA., Perry A; Department of Pathology, University of California San Francisco (UCSF), San Francisco, CA, USA.; Department of Neurological Surgery, University of California San Francisco (UCSF), San Francisco, CA, USA., Akanji O; Department of Neurosurgery, University Hospital Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany., Ratliff M; Department of Neurosurgery, University Hospital Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.; Clinical Cooperation Unit Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Herold-Mende C; Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany., Krieg SM; Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany., Wick W; Clinical Cooperation Unit Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Neurology and Neurooncology Program, European Center for Neurooncology (EZN), Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany., Pfister SM; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, University Hospital Heidelberg, Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.; Division of Pediatric Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Wesseling P; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Department of Pathology, Amsterdam University Medical Centers, Location VUmc and Brain Tumor Center Amsterdam, Amsterdam, The Netherlands., von Deimling A; Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany., Varlet P; Department of Neuropathology, GHU Paris, Psychiatry and Neurosciences, Sainte-Anne Hospital, Paris, France.; Université Paris Cité, Institute of Psychiatry and Neuroscience of Paris (IPNP), Paris, France., Sahm F; Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany., Sievers P; Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany. philipp.sievers@med.uni-heidelberg.de.; Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. philipp.sievers@med.uni-heidelberg.de.; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany. philipp.sievers@med.uni-heidelberg.de. |
| Source: | Nature communications [Nat Commun] 2026 Jul 14; Vol. 17 (1). Date of Electronic Publication: 2026 Jul 14. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-026-75357-2 |
