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Tritosomes-Digestion for LC-MS Conjugated Payloads Quantitation: A Universal Approach for Dual-Payloads ADCs.

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Title: Tritosomes-Digestion for LC-MS Conjugated Payloads Quantitation: A Universal Approach for Dual-Payloads ADCs.
Authors: Molinaro F; Innovative Bioanalytics, New Biological Entities, Drug Metabolism and Pharmacokinetics (NBE-DMPK), Research and Development, Merck Healthcare KGaA, RBM S.p.A.-Istituto di Ricerche Biomediche 'A. Marxer', an Affiliate of Merck KGaA, Via Ribes 1, 10010 Colleretto Giacosa, TO, Italy., Colangelo GS; Innovative Bioanalytics, New Biological Entities, Drug Metabolism and Pharmacokinetics (NBE-DMPK), Research and Development, Merck Healthcare KGaA, RBM S.p.A.-Istituto di Ricerche Biomediche 'A. Marxer', an Affiliate of Merck KGaA, Via Ribes 1, 10010 Colleretto Giacosa, TO, Italy., Cocco P; Innovative Bioanalytics, New Biological Entities, Drug Metabolism and Pharmacokinetics (NBE-DMPK), Research and Development, Merck Healthcare KGaA, RBM S.p.A.-Istituto di Ricerche Biomediche 'A. Marxer', an Affiliate of Merck KGaA, Via Ribes 1, 10010 Colleretto Giacosa, TO, Italy., Di Ianni A; Innovative Bioanalytics, New Biological Entities, Drug Metabolism and Pharmacokinetics (NBE-DMPK), Research and Development, Merck Healthcare KGaA, RBM S.p.A.-Istituto di Ricerche Biomediche 'A. Marxer', an Affiliate of Merck KGaA, Via Ribes 1, 10010 Colleretto Giacosa, TO, Italy., Knapp-Buehle D; New Biological Entities, Drug Metabolism and Pharmacokinetics (NBE-DMPK), Research and Development, Merck Healthcare KGaA, Frankfurter Strasse 250, 64293 Darmstadt, Germany., Paoletti A; Innovative Bioanalytics, New Biological Entities, Drug Metabolism and Pharmacokinetics (NBE-DMPK), Research and Development, Merck Healthcare KGaA, RBM S.p.A.-Istituto di Ricerche Biomediche 'A. Marxer', an Affiliate of Merck KGaA, Via Ribes 1, 10010 Colleretto Giacosa, TO, Italy., Bertotti E; Innovative Bioanalytics, New Biological Entities, Drug Metabolism and Pharmacokinetics (NBE-DMPK), Research and Development, Merck Healthcare KGaA, RBM S.p.A.-Istituto di Ricerche Biomediche 'A. Marxer', an Affiliate of Merck KGaA, Via Ribes 1, 10010 Colleretto Giacosa, TO, Italy., Cowan K; New Biological Entities, Drug Metabolism and Pharmacokinetics (NBE-DMPK), Research and Development, Merck Healthcare KGaA, Frankfurter Strasse 250, 64293 Darmstadt, Germany., Riccardi Sirtori F; Innovative Bioanalytics, New Biological Entities, Drug Metabolism and Pharmacokinetics (NBE-DMPK), Research and Development, Merck Healthcare KGaA, RBM S.p.A.-Istituto di Ricerche Biomediche 'A. Marxer', an Affiliate of Merck KGaA, Via Ribes 1, 10010 Colleretto Giacosa, TO, Italy., Barbero L; Innovative Bioanalytics, New Biological Entities, Drug Metabolism and Pharmacokinetics (NBE-DMPK), Research and Development, Merck Healthcare KGaA, RBM S.p.A.-Istituto di Ricerche Biomediche 'A. Marxer', an Affiliate of Merck KGaA, Via Ribes 1, 10010 Colleretto Giacosa, TO, Italy.
Source: International journal of molecular sciences [Int J Mol Sci] 2026 Jun 29; Vol. 27 (13). Date of Electronic Publication: 2026 Jun 29.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1422-0067
DOI:10.3390/ijms27135874