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AC3® exerts cytotoxic and anti-migratory activity and modulates the gene expression of TNF-α, inflammatory mediators, and components of the CD39/CD73/adenosine axis in cutaneous melanoma cell lines.

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Title: AC3® exerts cytotoxic and anti-migratory activity and modulates the gene expression of TNF-α, inflammatory mediators, and components of the CD39/CD73/adenosine axis in cutaneous melanoma cell lines.
Authors: Manica D; Postgraduate Program in Biochemistry, Federal University of Santa Catarina, Florianópolis, SC, Brazil.; LaBioSignal - Laboratory of Biochemistry and Cell Signal, Department of Biochemistry, Federal University of Santa Catarina, Florianópolis, SC, Brazil., da Silva GB; Multicentric Postgraduate Program in Biochemistry and Molecular Biology, State University of Santa Catarina, Lages, SC, Brazil., Ozelame BC; Postgraduate Program in Health Sciences, Community University of the Chapecó Region (Unochapecó), Chapecó, SC, Brazil., de Mello VC; Postgraduate Program in Biomedical Sciences, Federal University of Fronteira Sul, Chapecó, SC, Brazil., da Rosa VA; Postgraduate Program in Biomedical Sciences, Federal University of Fronteira Sul, Chapecó, SC, Brazil., Ortmann C; Sabinsa Brasil, Florianópolis, Santa Catarina, Brazil., de Camargo IDBB; Sabinsa Brasil, Florianópolis, Santa Catarina, Brazil., Majeed A; Sami-Sabinsa Group, Bangalore, Karnataka, India., Majeed S; Sabinsa Corporation, Payson, UT, USA., Kempka AP; Multicentric Postgraduate Program in Biochemistry and Molecular Biology, State University of Santa Catarina, Lages, SC, Brazil., Zamoner A; Postgraduate Program in Biochemistry, Federal University of Santa Catarina, Florianópolis, SC, Brazil.; LaBioSignal - Laboratory of Biochemistry and Cell Signal, Department of Biochemistry, Federal University of Santa Catarina, Florianópolis, SC, Brazil., Bagatini MD; Postgraduate Program in Biochemistry, Federal University of Santa Catarina, Florianópolis, SC, Brazil. margarete.bagatini@uffs.edu.br.; Postgraduate Program in Biomedical Sciences, Federal University of Fronteira Sul, Chapecó, SC, Brazil. margarete.bagatini@uffs.edu.br.; Federal University of Southern Frontier , SC 484, Km 02, Southern Frontier, Chapecó, SC, 89812000, Brazil. margarete.bagatini@uffs.edu.br.
Source: Medical oncology (Northwood, London, England) [Med Oncol] 2026 Jul 15; Vol. 43 (9). Date of Electronic Publication: 2026 Jul 15.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 9435512 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-131X (Electronic) Linking ISSN: 13570560 NLM ISO Abbreviation: Med Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1559-131X
DOI:10.1007/s12032-026-03321-7