AC3® exerts cytotoxic and anti-migratory activity and modulates the gene expression of TNF-α, inflammatory mediators, and components of the CD39/CD73/adenosine axis in cutaneous melanoma cell lines.
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| Title: | AC3® exerts cytotoxic and anti-migratory activity and modulates the gene expression of TNF-α, inflammatory mediators, and components of the CD39/CD73/adenosine axis in cutaneous melanoma cell lines. |
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| Authors: | Manica D; Postgraduate Program in Biochemistry, Federal University of Santa Catarina, Florianópolis, SC, Brazil.; LaBioSignal - Laboratory of Biochemistry and Cell Signal, Department of Biochemistry, Federal University of Santa Catarina, Florianópolis, SC, Brazil., da Silva GB; Multicentric Postgraduate Program in Biochemistry and Molecular Biology, State University of Santa Catarina, Lages, SC, Brazil., Ozelame BC; Postgraduate Program in Health Sciences, Community University of the Chapecó Region (Unochapecó), Chapecó, SC, Brazil., de Mello VC; Postgraduate Program in Biomedical Sciences, Federal University of Fronteira Sul, Chapecó, SC, Brazil., da Rosa VA; Postgraduate Program in Biomedical Sciences, Federal University of Fronteira Sul, Chapecó, SC, Brazil., Ortmann C; Sabinsa Brasil, Florianópolis, Santa Catarina, Brazil., de Camargo IDBB; Sabinsa Brasil, Florianópolis, Santa Catarina, Brazil., Majeed A; Sami-Sabinsa Group, Bangalore, Karnataka, India., Majeed S; Sabinsa Corporation, Payson, UT, USA., Kempka AP; Multicentric Postgraduate Program in Biochemistry and Molecular Biology, State University of Santa Catarina, Lages, SC, Brazil., Zamoner A; Postgraduate Program in Biochemistry, Federal University of Santa Catarina, Florianópolis, SC, Brazil.; LaBioSignal - Laboratory of Biochemistry and Cell Signal, Department of Biochemistry, Federal University of Santa Catarina, Florianópolis, SC, Brazil., Bagatini MD; Postgraduate Program in Biochemistry, Federal University of Santa Catarina, Florianópolis, SC, Brazil. margarete.bagatini@uffs.edu.br.; Postgraduate Program in Biomedical Sciences, Federal University of Fronteira Sul, Chapecó, SC, Brazil. margarete.bagatini@uffs.edu.br.; Federal University of Southern Frontier , SC 484, Km 02, Southern Frontier, Chapecó, SC, 89812000, Brazil. margarete.bagatini@uffs.edu.br. |
| Source: | Medical oncology (Northwood, London, England) [Med Oncol] 2026 Jul 15; Vol. 43 (9). Date of Electronic Publication: 2026 Jul 15. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Country of Publication: United States NLM ID: 9435512 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-131X (Electronic) Linking ISSN: 13570560 NLM ISO Abbreviation: Med Oncol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42455469 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: AC3<superscript>®</superscript> exerts cytotoxic and anti-migratory activity and modulates the gene expression of TNF-α, inflammatory mediators, and components of the CD39/CD73/adenosine axis in cutaneous melanoma cell lines. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Manica+D%22">Manica D</searchLink>; Postgraduate Program in Biochemistry, Federal University of Santa Catarina, Florianópolis, SC, Brazil.; LaBioSignal - Laboratory of Biochemistry and Cell Signal, Department of Biochemistry, Federal University of Santa Catarina, Florianópolis, SC, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Silva+GB%22">da Silva GB</searchLink>; Multicentric Postgraduate Program in Biochemistry and Molecular Biology, State University of Santa Catarina, Lages, SC, Brazil.<br /><searchLink fieldCode="AU" term="%22Ozelame+BC%22">Ozelame BC</searchLink>; Postgraduate Program in Health Sciences, Community University of the Chapecó Region (Unochapecó), Chapecó, SC, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Mello+VC%22">de Mello VC</searchLink>; Postgraduate Program in Biomedical Sciences, Federal University of Fronteira Sul, Chapecó, SC, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Rosa+VA%22">da Rosa VA</searchLink>; Postgraduate Program in Biomedical Sciences, Federal University of Fronteira Sul, Chapecó, SC, Brazil.<br /><searchLink fieldCode="AU" term="%22Ortmann+C%22">Ortmann C</searchLink>; Sabinsa Brasil, Florianópolis, Santa Catarina, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Camargo+IDBB%22">de Camargo IDBB</searchLink>; Sabinsa Brasil, Florianópolis, Santa Catarina, Brazil.<br /><searchLink fieldCode="AU" term="%22Majeed+A%22">Majeed A</searchLink>; Sami-Sabinsa Group, Bangalore, Karnataka, India.<br /><searchLink fieldCode="AU" term="%22Majeed+S%22">Majeed S</searchLink>; Sabinsa Corporation, Payson, UT, USA.<br /><searchLink fieldCode="AU" term="%22Kempka+AP%22">Kempka AP</searchLink>; Multicentric Postgraduate Program in Biochemistry and Molecular Biology, State University of Santa Catarina, Lages, SC, Brazil.<br /><searchLink fieldCode="AU" term="%22Zamoner+A%22">Zamoner A</searchLink>; Postgraduate Program in Biochemistry, Federal University of Santa Catarina, Florianópolis, SC, Brazil.; LaBioSignal - Laboratory of Biochemistry and Cell Signal, Department of Biochemistry, Federal University of Santa Catarina, Florianópolis, SC, Brazil.<br /><searchLink fieldCode="AU" term="%22Bagatini+MD%22">Bagatini MD</searchLink>; Postgraduate Program in Biochemistry, Federal University of Santa Catarina, Florianópolis, SC, Brazil. margarete.bagatini@uffs.edu.br.; Postgraduate Program in Biomedical Sciences, Federal University of Fronteira Sul, Chapecó, SC, Brazil. margarete.bagatini@uffs.edu.br.; Federal University of Southern Frontier , SC 484, Km 02, Southern Frontier, Chapecó, SC, 89812000, Brazil. margarete.bagatini@uffs.edu.br. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229435512%22">Medical oncology (Northwood, London, England)</searchLink> [Med Oncol] 2026 Jul 15; Vol. 43 (9). <i>Date of Electronic Publication: </i>2026 Jul 15. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9435512 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1559-131X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213570560%22">13570560 </searchLink><i>NLM ISO Abbreviation: </i>Med Oncol <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42455469 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s12032-026-03321-7 Languages: – Code: eng Text: English Titles: – TitleFull: AC3® exerts cytotoxic and anti-migratory activity and modulates the gene expression of TNF-α, inflammatory mediators, and components of the CD39/CD73/adenosine axis in cutaneous melanoma cell lines. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Manica D – PersonEntity: Name: NameFull: da Silva GB – PersonEntity: Name: NameFull: Ozelame BC – PersonEntity: Name: NameFull: de Mello VC – PersonEntity: Name: NameFull: da Rosa VA – PersonEntity: Name: NameFull: Ortmann C – PersonEntity: Name: NameFull: de Camargo IDBB – PersonEntity: Name: NameFull: Majeed A – PersonEntity: Name: NameFull: Majeed S – PersonEntity: Name: NameFull: Kempka AP – PersonEntity: Name: NameFull: Zamoner A – PersonEntity: Name: NameFull: Bagatini MD IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 07 Text: 2026 Jul 15 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1559-131X Numbering: – Type: volume Value: 43 – Type: issue Value: 9 Titles: – TitleFull: Medical oncology (Northwood, London, England) Type: main |
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