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A controlled-release mitochondrial protonophore attenuates early- and late-stage atheroprogression in mice.

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Title: A controlled-release mitochondrial protonophore attenuates early- and late-stage atheroprogression in mice.
Authors: Dos Santos BG; Department of Medicine (Cardiology), Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Brisnovali NF; Department of Medicine (Cardiology), Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Haney C; Department of Medicine (Cardiology), Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Coven M; Department of Medicine (Cardiology), Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Sebzevari HL; Department of Medicine (Cardiology), Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Gaebel L; Department of Medicine (Cardiology), Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Zhang X; Vascular Biology and Therapeutics Program, Yale School of Medicine, New Haven, CT 06510, USA.; Integrative Cell Signaling and Neurobiology of Metabolism Program, Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06510, USA., Sun J; Vascular Biology and Therapeutics Program, Yale School of Medicine, New Haven, CT 06510, USA.; Integrative Cell Signaling and Neurobiology of Metabolism Program, Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06510, USA.; Department of Pathology, Yale School of Medicine, New Haven, CT 06510, USA., Canfrán-Duque A; Vascular Biology and Therapeutics Program, Yale School of Medicine, New Haven, CT 06510, USA.; Integrative Cell Signaling and Neurobiology of Metabolism Program, Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06510, USA., Rotllan N; Vascular Biology and Therapeutics Program, Yale School of Medicine, New Haven, CT 06510, USA.; Integrative Cell Signaling and Neurobiology of Metabolism Program, Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06510, USA., Nasiri A; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA., Kahn M; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA., McAlpine CS; Department of Medicine (Cardiology), Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Shulman GI; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA.; Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT 06510, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA., Goedeke L; Department of Medicine (Cardiology), Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Medicine (Endocrinology), Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Source: Science translational medicine [Sci Transl Med] 2026 Jul 15; Vol. 18 (858), pp. eadv1815. Date of Electronic Publication: 2026 Jul 15.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A controlled-release mitochondrial protonophore attenuates early- and late-stage atheroprogression in mice.
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  Data: <searchLink fieldCode="AU" term="%22Dos+Santos+BG%22">Dos Santos BG</searchLink>; Department of Medicine (Cardiology), Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Brisnovali+NF%22">Brisnovali NF</searchLink>; Department of Medicine (Cardiology), Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Haney+C%22">Haney C</searchLink>; Department of Medicine (Cardiology), Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Coven+M%22">Coven M</searchLink>; Department of Medicine (Cardiology), Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Sebzevari+HL%22">Sebzevari HL</searchLink>; Department of Medicine (Cardiology), Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Gaebel+L%22">Gaebel L</searchLink>; Department of Medicine (Cardiology), Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Vascular Biology and Therapeutics Program, Yale School of Medicine, New Haven, CT 06510, USA.; Integrative Cell Signaling and Neurobiology of Metabolism Program, Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06510, USA.<br /><searchLink fieldCode="AU" term="%22Sun+J%22">Sun J</searchLink>; Vascular Biology and Therapeutics Program, Yale School of Medicine, New Haven, CT 06510, USA.; Integrative Cell Signaling and Neurobiology of Metabolism Program, Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06510, USA.; Department of Pathology, Yale School of Medicine, New Haven, CT 06510, USA.<br /><searchLink fieldCode="AU" term="%22Canfrán-Duque+A%22">Canfrán-Duque A</searchLink>; Vascular Biology and Therapeutics Program, Yale School of Medicine, New Haven, CT 06510, USA.; Integrative Cell Signaling and Neurobiology of Metabolism Program, Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06510, USA.<br /><searchLink fieldCode="AU" term="%22Rotllan+N%22">Rotllan N</searchLink>; Vascular Biology and Therapeutics Program, Yale School of Medicine, New Haven, CT 06510, USA.; Integrative Cell Signaling and Neurobiology of Metabolism Program, Department of Comparative Medicine, Yale School of Medicine, New Haven, CT 06510, USA.<br /><searchLink fieldCode="AU" term="%22Nasiri+A%22">Nasiri A</searchLink>; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA.<br /><searchLink fieldCode="AU" term="%22Kahn+M%22">Kahn M</searchLink>; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA.<br /><searchLink fieldCode="AU" term="%22McAlpine+CS%22">McAlpine CS</searchLink>; Department of Medicine (Cardiology), Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.<br /><searchLink fieldCode="AU" term="%22Shulman+GI%22">Shulman GI</searchLink>; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA.; Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT 06510, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.<br /><searchLink fieldCode="AU" term="%22Goedeke+L%22">Goedeke L</searchLink>; Department of Medicine (Cardiology), Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Department of Medicine (Endocrinology), Diabetes, Obesity and Metabolism Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
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