Poly(I:C)-stimulated alveolar macrophages modulate extracellular matrix turnover and fibroblast activation through cystatin 6 and cathepsin B.

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Title: Poly(I:C)-stimulated alveolar macrophages modulate extracellular matrix turnover and fibroblast activation through cystatin 6 and cathepsin B.
Authors: Chang CN; Institute of Translational Medicine and New Drug Development, China Medical University, No.91 Hsueh-Shih Road, Taichung, 404333, Taiwan., Tsai CF; Department of Medical Laboratory Science and Biotechnology, Asia University, No.500 Lioufeng Road, Taichung, 413305, Taiwan., Chen YC; Institute of Translational Medicine and New Drug Development, China Medical University, No.91 Hsueh-Shih Road, Taichung, 404333, Taiwan., Chen CW; Institute of Translational Medicine and New Drug Development, China Medical University, No.91 Hsueh-Shih Road, Taichung, 404333, Taiwan., Wang YW; Department of Biotechnology and Pharmaceutical Technology, Yuanpei University of Medical Technology, Hsinchu, 300102, Taiwan; Department of Nursing and Graduate Institute of Nursing, Asia University, No.500 Lioufeng Road, Taichung, 413305, Taiwan., Chiou YC; Department of Biological Science and Technology, China Medical University, No.91 Hsueh-Shih Road, Taichung, 404333, Taiwan., Lu DY; Graduate Institute of Biomedical Sciences, China Medical University, No.91 Hsueh-Shih Road, Taichung, 404333, Taiwan; Department of Pharmacology, School of Medicine, China Medical University, No.91 Hsueh-Shih Road, Taichung, 404333, Taiwan; Office of Research and Development, Asia University, No.500 Lioufeng Road, Taichung, 413305, Taiwan. Electronic address: dahyuu@mail.cmu.edu.tw., Yeh WL; Institute of Translational Medicine and New Drug Development, China Medical University, No.91 Hsueh-Shih Road, Taichung, 404333, Taiwan; Department of Biochemistry, School of Medicine, China Medical University, No.91 Hsueh-Shih Road, Taichung, 404333, Taiwan. Electronic address: wlyeh@mail.cmu.edu.tw.
Source: European journal of pharmacology [Eur J Pharmacol] 2026 Jul 15; Vol. 1030, pp. 179149. Date of Electronic Publication: 2026 Jul 15.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1879-0712
DOI:10.1016/j.ejphar.2026.179149