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Poly(I:C)-stimulated alveolar macrophages modulate extracellular matrix turnover and fibroblast activation through cystatin 6 and cathepsin B.

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Title: Poly(I:C)-stimulated alveolar macrophages modulate extracellular matrix turnover and fibroblast activation through cystatin 6 and cathepsin B.
Authors: Chang CN; Institute of Translational Medicine and New Drug Development, China Medical University, No.91 Hsueh-Shih Road, Taichung, 404333, Taiwan., Tsai CF; Department of Medical Laboratory Science and Biotechnology, Asia University, No.500 Lioufeng Road, Taichung, 413305, Taiwan., Chen YC; Institute of Translational Medicine and New Drug Development, China Medical University, No.91 Hsueh-Shih Road, Taichung, 404333, Taiwan., Chen CW; Institute of Translational Medicine and New Drug Development, China Medical University, No.91 Hsueh-Shih Road, Taichung, 404333, Taiwan., Wang YW; Department of Biotechnology and Pharmaceutical Technology, Yuanpei University of Medical Technology, Hsinchu, 300102, Taiwan; Department of Nursing and Graduate Institute of Nursing, Asia University, No.500 Lioufeng Road, Taichung, 413305, Taiwan., Chiou YC; Department of Biological Science and Technology, China Medical University, No.91 Hsueh-Shih Road, Taichung, 404333, Taiwan., Lu DY; Graduate Institute of Biomedical Sciences, China Medical University, No.91 Hsueh-Shih Road, Taichung, 404333, Taiwan; Department of Pharmacology, School of Medicine, China Medical University, No.91 Hsueh-Shih Road, Taichung, 404333, Taiwan; Office of Research and Development, Asia University, No.500 Lioufeng Road, Taichung, 413305, Taiwan. Electronic address: dahyuu@mail.cmu.edu.tw., Yeh WL; Institute of Translational Medicine and New Drug Development, China Medical University, No.91 Hsueh-Shih Road, Taichung, 404333, Taiwan; Department of Biochemistry, School of Medicine, China Medical University, No.91 Hsueh-Shih Road, Taichung, 404333, Taiwan. Electronic address: wlyeh@mail.cmu.edu.tw.
Source: European journal of pharmacology [Eur J Pharmacol] 2026 Jul 15; Vol. 1030, pp. 179149. Date of Electronic Publication: 2026 Jul 15.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Poly(I:C)-stimulated alveolar macrophages modulate extracellular matrix turnover and fibroblast activation through cystatin 6 and cathepsin B.
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  Data: <searchLink fieldCode="AU" term="%22Chang+CN%22">Chang CN</searchLink>; Institute of Translational Medicine and New Drug Development, China Medical University, No.91 Hsueh-Shih Road, Taichung, 404333, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tsai+CF%22">Tsai CF</searchLink>; Department of Medical Laboratory Science and Biotechnology, Asia University, No.500 Lioufeng Road, Taichung, 413305, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YC%22">Chen YC</searchLink>; Institute of Translational Medicine and New Drug Development, China Medical University, No.91 Hsueh-Shih Road, Taichung, 404333, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+CW%22">Chen CW</searchLink>; Institute of Translational Medicine and New Drug Development, China Medical University, No.91 Hsueh-Shih Road, Taichung, 404333, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+YW%22">Wang YW</searchLink>; Department of Biotechnology and Pharmaceutical Technology, Yuanpei University of Medical Technology, Hsinchu, 300102, Taiwan; Department of Nursing and Graduate Institute of Nursing, Asia University, No.500 Lioufeng Road, Taichung, 413305, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chiou+YC%22">Chiou YC</searchLink>; Department of Biological Science and Technology, China Medical University, No.91 Hsueh-Shih Road, Taichung, 404333, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lu+DY%22">Lu DY</searchLink>; Graduate Institute of Biomedical Sciences, China Medical University, No.91 Hsueh-Shih Road, Taichung, 404333, Taiwan; Department of Pharmacology, School of Medicine, China Medical University, No.91 Hsueh-Shih Road, Taichung, 404333, Taiwan; Office of Research and Development, Asia University, No.500 Lioufeng Road, Taichung, 413305, Taiwan. Electronic address: dahyuu@mail.cmu.edu.tw.<br /><searchLink fieldCode="AU" term="%22Yeh+WL%22">Yeh WL</searchLink>; Institute of Translational Medicine and New Drug Development, China Medical University, No.91 Hsueh-Shih Road, Taichung, 404333, Taiwan; Department of Biochemistry, School of Medicine, China Medical University, No.91 Hsueh-Shih Road, Taichung, 404333, Taiwan. Electronic address: wlyeh@mail.cmu.edu.tw.
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  Data: <searchLink fieldCode="JN" term="%221254354%22">European journal of pharmacology</searchLink> [Eur J Pharmacol] 2026 Jul 15; Vol. 1030, pp. 179149. <i>Date of Electronic Publication: </i>2026 Jul 15.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>1254354 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-0712 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200142999%22">00142999 </searchLink><i>NLM ISO Abbreviation: </i>Eur J Pharmacol <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.ejphar.2026.179149
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        Text: English
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              Text: 2026 Jul 15
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