Bispecific antibody against sclerostin and DKK1 improves bone health and reduces bone marrow adipose tissue accumulation in experimental chronic kidney disease.
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| Title: | Bispecific antibody against sclerostin and DKK1 improves bone health and reduces bone marrow adipose tissue accumulation in experimental chronic kidney disease. |
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| Authors: | Promruk W; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK. W.Promruk@sms.ed.ac.uk.; Chulabhorn Royal Academy, Bangkok, Thailand. W.Promruk@sms.ed.ac.uk., Jayash SN; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK., Chutoe C; Edinburgh Cancer Research UK Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Ke HZ; Angitia Biopharmaceuticals (Angitia Incorporated Limited), Guangzhou, China and Westlake Village, Westlake Village, CA, USA., Liu X; Angitia Biopharmaceuticals (Angitia Incorporated Limited), Guangzhou, China and Westlake Village, Westlake Village, CA, USA., Wade RL; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK., von Kriegsheim A; Edinburgh Cancer Research UK Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Cawthorn WP; Institute for Neuroscience and Cardiovascular Research, Edinburgh Bioquarter, University of Edinburgh, Edinburgh, UK., Staines KA; Centre for Lifelong Health, School of Applied Sciences, University of Brighton, Brighton, UK., Stephen LA; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK., Farquharson C; The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK. colin.farquharson@roslin.ed.ac.uk. |
| Source: | Bone research [Bone Res] 2026 Jul 15; Vol. 14 (1). Date of Electronic Publication: 2026 Jul 15. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: West China School of Stomatology, Sichuan University Country of Publication: China NLM ID: 101608652 Publication Model: Electronic Cited Medium: Print ISSN: 2095-4700 (Print) Linking ISSN: 20954700 NLM ISO Abbreviation: Bone Res Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2095-4700 |
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| DOI: | 10.1038/s41413-026-00556-y |
